Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling

• Published in: Frontiers in pharmacology Vol. 11; p. 601716
• Main Authors: Xu, Qiushi, Fan, Yunhui, Loor, Juan J., Liang, Yusheng, Sun, Xudong, Jia, Hongdou, Zhao, Chenxu, Xu, Chuang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.11.2020
• Subjects: acetaminophen; acute liver injury; autophagy; cardamonin; NFE2L2; Pharmacology; acetaminophen; autophagy; cardamonin; NFE2L2; acute liver injury

Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen- (APAP-) induced hepatotoxicity remains elusive. The objective of this study was to determine the prot...