Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling
Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen- (APAP-) induced hepatotoxicity remains elusive. The objective of this study was to determine the prot...
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| Published in | Frontiers in pharmacology Vol. 11; p. 601716 |
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| Main Authors | , , , , , , , |
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| Language | English |
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| Abstract | Cardamonin (CD), a naturally occurring chalcone derived from the
Alpinia
species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen- (APAP-) induced hepatotoxicity remains elusive. The objective of this study was to determine the protective effects of CD against APAP-induced acute liver injury (ALI) and the underlying mechanisms. Wild-type or transcription factor nuclear factor erythroid 2-related factor 2- (NFE2L2-) deficient mice were treated with CD (50 or 100 mg/kg, i.p.) or vehicle for 24 h. Subsequently, these mice were challenged with APAP (400 mg/kg, i.p.) for 6 h. Liver and blood samples were collected to evaluate liver injury and protein abundance. Treatment with CD significantly reduced APAP-induced hepatotoxicity. Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling. In addition, CD induced activation of sequestosome 1 (p62) and NFE2L2 signaling and facilitated autophagy. By applying autophagy inhibitor 3-methyladenine (3-MA; 20 mg/kg, i.p.), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2
−/−
mice. Overall, data suggest that CD has hepatoprotective effect against APAP-induced ALI, which might contribute to the activation of NFE2L2 and autophagy. |
|---|---|
| AbstractList | Cardamonin (CD), a naturally occurring chalcone derived from the
Alpinia
species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen- (APAP-) induced hepatotoxicity remains elusive. The objective of this study was to determine the protective effects of CD against APAP-induced acute liver injury (ALI) and the underlying mechanisms. Wild-type or transcription factor nuclear factor erythroid 2-related factor 2- (NFE2L2-) deficient mice were treated with CD (50 or 100 mg/kg, i.p.) or vehicle for 24 h. Subsequently, these mice were challenged with APAP (400 mg/kg, i.p.) for 6 h. Liver and blood samples were collected to evaluate liver injury and protein abundance. Treatment with CD significantly reduced APAP-induced hepatotoxicity. Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling. In addition, CD induced activation of sequestosome 1 (p62) and NFE2L2 signaling and facilitated autophagy. By applying autophagy inhibitor 3-methyladenine (3-MA; 20 mg/kg, i.p.), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2
−/−
mice. Overall, data suggest that CD has hepatoprotective effect against APAP-induced ALI, which might contribute to the activation of NFE2L2 and autophagy. Cardamonin (CD), a naturally occurring chalcone derived from the species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen- (APAP-) induced hepatotoxicity remains elusive. The objective of this study was to determine the protective effects of CD against APAP-induced acute liver injury (ALI) and the underlying mechanisms. Wild-type or transcription factor nuclear factor erythroid 2-related factor 2- (NFE2L2-) deficient mice were treated with CD (50 or 100 mg/kg, i.p.) or vehicle for 24 h. Subsequently, these mice were challenged with APAP (400 mg/kg, i.p.) for 6 h. Liver and blood samples were collected to evaluate liver injury and protein abundance. Treatment with CD significantly reduced APAP-induced hepatotoxicity. Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling. In addition, CD induced activation of sequestosome 1 (p62) and NFE2L2 signaling and facilitated autophagy. By applying autophagy inhibitor 3-methyladenine (3-MA; 20 mg/kg, i.p.), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2 mice. Overall, data suggest that CD has hepatoprotective effect against APAP-induced ALI, which might contribute to the activation of NFE2L2 and autophagy. Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen- (APAP-) induced hepatotoxicity remains elusive. The objective of this study was to determine the protective effects of CD against APAP-induced acute liver injury (ALI) and the underlying mechanisms. Wild-type or transcription factor nuclear factor erythroid 2-related factor 2- (NFE2L2-) deficient mice were treated with CD (50 or 100 mg/kg, i.p.) or vehicle for 24 h. Subsequently, these mice were challenged with APAP (400 mg/kg, i.p.) for 6 h. Liver and blood samples were collected to evaluate liver injury and protein abundance. Treatment with CD significantly reduced APAP-induced hepatotoxicity. Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling. In addition, CD induced activation of sequestosome 1 (p62) and NFE2L2 signaling and facilitated autophagy. By applying autophagy inhibitor 3-methyladenine (3-MA; 20 mg/kg, i.p.), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2−/− mice. Overall, data suggest that CD has hepatoprotective effect against APAP-induced ALI, which might contribute to the activation of NFE2L2 and autophagy. Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen- (APAP-) induced hepatotoxicity remains elusive. The objective of this study was to determine the protective effects of CD against APAP-induced acute liver injury (ALI) and the underlying mechanisms. Wild-type or transcription factor nuclear factor erythroid 2-related factor 2- (NFE2L2-) deficient mice were treated with CD (50 or 100 mg/kg, i.p.) or vehicle for 24 h. Subsequently, these mice were challenged with APAP (400 mg/kg, i.p.) for 6 h. Liver and blood samples were collected to evaluate liver injury and protein abundance. Treatment with CD significantly reduced APAP-induced hepatotoxicity. Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling. In addition, CD induced activation of sequestosome 1 (p62) and NFE2L2 signaling and facilitated autophagy. By applying autophagy inhibitor 3-methyladenine (3-MA; 20 mg/kg, i.p.), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2-/- mice. Overall, data suggest that CD has hepatoprotective effect against APAP-induced ALI, which might contribute to the activation of NFE2L2 and autophagy.Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen- (APAP-) induced hepatotoxicity remains elusive. The objective of this study was to determine the protective effects of CD against APAP-induced acute liver injury (ALI) and the underlying mechanisms. Wild-type or transcription factor nuclear factor erythroid 2-related factor 2- (NFE2L2-) deficient mice were treated with CD (50 or 100 mg/kg, i.p.) or vehicle for 24 h. Subsequently, these mice were challenged with APAP (400 mg/kg, i.p.) for 6 h. Liver and blood samples were collected to evaluate liver injury and protein abundance. Treatment with CD significantly reduced APAP-induced hepatotoxicity. Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling. In addition, CD induced activation of sequestosome 1 (p62) and NFE2L2 signaling and facilitated autophagy. By applying autophagy inhibitor 3-methyladenine (3-MA; 20 mg/kg, i.p.), further mechanistic exploration revealed that NFE2L2 deficiency promoted autophagic activity induced by CD treatment, which was conducive to the hepatoprotective effect of CD against APAP-induced hepatoxicity in NFE2L2-/- mice. Overall, data suggest that CD has hepatoprotective effect against APAP-induced ALI, which might contribute to the activation of NFE2L2 and autophagy. |
| Author | Fan, Yunhui Loor, Juan J. Sun, Xudong Jia, Hongdou Liang, Yusheng Zhao, Chenxu Xu, Chuang Xu, Qiushi |
| AuthorAffiliation | 1 College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing , China 2 Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana , IL , United States |
| AuthorAffiliation_xml | – name: 1 College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing , China – name: 2 Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana , IL , United States |
| Author_xml | – sequence: 1 givenname: Qiushi surname: Xu fullname: Xu, Qiushi – sequence: 2 givenname: Yunhui surname: Fan fullname: Fan, Yunhui – sequence: 3 givenname: Juan J. surname: Loor fullname: Loor, Juan J. – sequence: 4 givenname: Yusheng surname: Liang fullname: Liang, Yusheng – sequence: 5 givenname: Xudong surname: Sun fullname: Sun, Xudong – sequence: 6 givenname: Hongdou surname: Jia fullname: Jia, Hongdou – sequence: 7 givenname: Chenxu surname: Zhao fullname: Zhao, Chenxu – sequence: 8 givenname: Chuang surname: Xu fullname: Xu, Chuang |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33364966$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1080/20014091111677 10.1016/j.intimp.2017.05.001 10.1016/j.redox.2016.10.001 10.2119/molmed.2010.00126 10.1016/j.molcel.2013.08.003 10.1016/j.lfs.2016.02.002 10.1016/j.ejphar.2017.09.037 10.1016/j.bmcl.2015.04.054 10.1080/15548627.2016.1235124 10.1039/c8fo00650d 10.1074/jbc.m112.439547 10.1111/j.1478-3231.2011.02501.x 10.1016/j.abb.2016.06.004 10.1002/hep.26320 10.1016/j.cld.2007.06.001 10.18632/oncotarget.3047 10.3389/fphar.2018.00147 10.1038/ncb2788 10.1016/j.cotox.2016.09.005 10.14218/JCTH.2014.00014 10.1016/j.jhep.2016.11.017 10.1016/j.bbadis.2017.12.027 10.1159/000136531 10.1016/j.taap.2006.04.010 10.1038/90609 10.1038/nrd1750 10.1016/j.mrfmmm.2009.09.007 10.1038/s41419-019-1543-z 10.1164/ajrccm.164.10.2106117 10.1016/j.tcm.2012.05.015 10.1016/j.jhep.2011.12.019 10.2353/ajpath.2007.070188 10.1089/jmf.2013.0061 10.1016/j.pharep.2018.04.005 10.1002/jgm.1293 10.1073/pnas.081082098 10.1016/j.jss.2012.11.051 10.7326/0003-4819-137-12-200212170-00007 10.1007/978-3-642-00663-0_10 10.1016/j.redox.2018.04.019 10.1126/science.1204592 10.1016/j.freeradbiomed.2015.12.011 10.1371/journal.ppat.1003330 10.1039/c7fo00054e 10.1053/j.gastro.2012.09.008 10.1111/j.1478-3231.2010.02284.x |
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| Copyright | Copyright © 2020 Xu, Fan, Loor, Liang, Sun, Jia, Zhao and Xu. Copyright © 2020 Xu, Fan, Loor, Liang, Sun, Jia, Zhao and Xu Xu, Fan, Loor, Liang, Sun, Jia, Zhao and Xu |
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| Keywords | acetaminophen autophagy cardamonin NFE2L2 acute liver injury |
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| License | Copyright © 2020 Xu, Fan, Loor, Liang, Sun, Jia, Zhao and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Predictive Toxicology, a section of the journal Frontiers in Pharmacology Reviewed by: Bin Guo, Jilin University, China These authors have contributed equally to this work Zhigang Zhang, Northeast Agricultural University, China Yanfei Li, Northeast Agricultural University, China Edited by: Yanzhu Zhu, Chinese Academy of Agricultural Sciences (CAAS), China |
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| References | Boya (B6) 2013; 15 Katsuragi (B23) 2016; 1 Ichimura (B18) 2013; 51 Jaeschke (B19) 2012; 32 Williams (B43) 2010; 30 Shi (B40) 2018; 70 Kim (B24) 2010; 690 Lv (B30) 2018; 9 Jaeschke (B20) 2014; 2 Dong (B11) 2009; 11 Wang (B42) 2001; 164 Lv (B31) 2019; 10 Antoine (B3) 2010; 16 Bessems (B5) 2001; 31 Yan (B45) 2018; 17 Gonçalves (B14) 2014; 17 Du (B12) 2016; 10 Han (B17) 2016; 12 Ostapowicz (B34) 2002; 137 Rani (B36) 2016; 148 Kurahashi (B27) 2016; 604 Fisher (B13) 2013; 180 Gunawan (B15) 2007; 11 Kamo (B21) 2013; 58 Ding (B10) 2007; 171 Negash (B33) 2013; 9 Chan (B7) 2001; 98 Ryoo (B37) 2015; 6 Woolbright (B44) 2017; 66 Kim (B25) 2015; 25 Liu (B28); 1864 Liu (B29); 9 Akira (B1) 2001; 2 Yang (B46) 2017; 48 Kubes (B26) 2012; 143 Mitchell (B32) 1973; 187 Sanz-Garcia (B38) 2013; 288 De Spirt (B9) 2016; 91 Peng (B35) 2017; 8 Cover (B8) 2006; 216 Han (B16) 2010 Kaplowitz (B22) 2005; 4 Antoine (B2) 2012; 56 Settembre (B39) 2011; 332 Su (B41) 2011; 21 Atef (B4) 2017; 815 |
| References_xml | – volume: 31 start-page: 55 year: 2001 ident: B5 article-title: Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches publication-title: Crit. Rev. Toxicol. doi: 10.1080/20014091111677 – volume: 48 start-page: 91 year: 2017 ident: B46 article-title: Anti-oxidative and anti-inflammatory benefits of the ribonucleoside analogue 5-azacitidine in mice with acetaminophen-induced toxic hepatitis publication-title: Int. Immunopharm. doi: 10.1016/j.intimp.2017.05.001 – volume: 10 start-page: 148 year: 2016 ident: B12 article-title: Oxidative stress during acetaminophen hepatotoxicity: sources, pathophysiological role and therapeutic potential publication-title: Redox Biol. doi: 10.1016/j.redox.2016.10.001 – volume: 16 start-page: 479 year: 2010 ident: B3 article-title: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity publication-title: Mol. Med. doi: 10.2119/molmed.2010.00126 – volume: 51 start-page: 618 year: 2013 ident: B18 article-title: Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy publication-title: Mol. Cell doi: 10.1016/j.molcel.2013.08.003 – volume: 148 start-page: 183 year: 2016 ident: B36 article-title: Summary and conclusions publication-title: Life Sci. doi: 10.1016/j.lfs.2016.02.002 – volume: 815 start-page: 446 year: 2017 ident: B4 article-title: Effect of cardamonin on hepatic ischemia reperfusion induced in rats: role of nitric oxide publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2017.09.037 – volume: 25 start-page: 2559 year: 2015 ident: B25 article-title: Cardamonin induces autophagy and an antiproliferative effect through JNK activation in human colorectal carcinoma HCT116 cells publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2015.04.054 – volume: 12 start-page: 2326 year: 2016 ident: B17 article-title: Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice publication-title: Autophagy doi: 10.1080/15548627.2016.1235124 – volume: 9 start-page: 4184 ident: B29 article-title: Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation publication-title: Food Funct. doi: 10.1039/c8fo00650d – volume: 288 start-page: 15342 year: 2013 ident: B38 article-title: Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2 publication-title: J. Biol. Chem. doi: 10.1074/jbc.m112.439547 – volume: 32 start-page: 8 year: 2012 ident: B19 article-title: Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity publication-title: Liver Int. doi: 10.1111/j.1478-3231.2011.02501.x – volume: 604 start-page: 36 year: 2016 ident: B27 article-title: Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2016.06.004 – volume: 58 start-page: 351 year: 2013 ident: B21 article-title: ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury publication-title: Hepatology doi: 10.1002/hep.26320 – volume: 11 start-page: 459 year: 2007 ident: B15 article-title: Mechanisms of drug-induced liver disease publication-title: Clin. Liver Dis. doi: 10.1016/j.cld.2007.06.001 – volume: 6 start-page: 8167 year: 2015 ident: B37 article-title: Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells publication-title: Oncotarget doi: 10.18632/oncotarget.3047 – volume: 9 start-page: 147 year: 2018 ident: B30 article-title: Licochalcone A upregulates Nrf2 antioxidant pathway and thereby alleviates acetaminophen-induced hepatotoxicity publication-title: Front. Pharmacol. doi: 10.3389/fphar.2018.00147 – volume: 15 start-page: 713 year: 2013 ident: B6 article-title: Emerging regulation and functions of autophagy publication-title: Nat. Cell Biol. doi: 10.1038/ncb2788 – volume: 1 start-page: 54 year: 2016 ident: B23 article-title: Regulation of the Keap1-Nrf2 pathway by p62/SQSTM1 publication-title: Curr. Opin. Toxicol. doi: 10.1016/j.cotox.2016.09.005 – volume: 2 start-page: 153 year: 2014 ident: B20 article-title: Acetaminophen-induced liver injury: from animal models to humans publication-title: J. Clin. Transl. Hepatol. doi: 10.14218/JCTH.2014.00014 – volume: 66 start-page: 836 year: 2017 ident: B44 article-title: Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure publication-title: J. Hepatol. doi: 10.1016/j.jhep.2016.11.017 – volume: 1864 start-page: 764 ident: B28 article-title: Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation publication-title: Biochim. Biophys. Acta Mol. Basis Dis. doi: 10.1016/j.bbadis.2017.12.027 – volume: 187 start-page: 211 year: 1973 ident: B32 article-title: Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione publication-title: J. Pharmacol. Exp. Therapeut. doi: 10.1159/000136531 – volume: 216 start-page: 98 year: 2006 ident: B8 article-title: Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2006.04.010 – volume: 2 start-page: 675 year: 2001 ident: B1 article-title: Toll-like receptors: critical proteins linking innate and acquired immunity publication-title: Nat. Immunol. doi: 10.1038/90609 – volume: 4 start-page: 489 year: 2005 ident: B22 article-title: Idiosyncratic drug hepatotoxicity publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd1750 – volume: 690 start-page: 12 year: 2010 ident: B24 article-title: A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders publication-title: Mutat. Res. Fund Mol. Mech. Mutagen doi: 10.1016/j.mrfmmm.2009.09.007 – volume: 10 start-page: 1 year: 2019 ident: B31 article-title: Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A publication-title: Cell Death Dis. doi: 10.1038/s41419-019-1543-z – volume: 164 start-page: 1768 year: 2001 ident: B42 article-title: HMGB1 as a late mediator of lethal systemic inflammation publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/ajrccm.164.10.2106117 – volume: 21 start-page: 224 year: 2011 ident: B41 article-title: p62 stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress publication-title: Trends Cardiovasc. Med. doi: 10.1016/j.tcm.2012.05.015 – volume: 56 start-page: 1070 year: 2012 ident: B2 article-title: RETRACTED: molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity publication-title: J. Hepatol. doi: 10.1016/j.jhep.2011.12.019 – volume: 171 start-page: 513 year: 2007 ident: B10 article-title: Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2007.070188 – volume: 17 start-page: 633 year: 2014 ident: B14 article-title: An overview on cardamonin publication-title: J. Med. Food doi: 10.1089/jmf.2013.0061 – volume: 70 start-page: 908 year: 2018 ident: B40 article-title: Autophagy induced by cardamonin is associated with mTORC1 inhibition in SKOV3 cells publication-title: Pharmacol. Rep. doi: 10.1016/j.pharep.2018.04.005 – volume: 11 start-page: 229 year: 2009 ident: B11 article-title: Reduction of liver tumor necrosis factor-α expression by targeting delivery of antisense oligonucleotides into Kupffer cells protects rats from fulminant hepatitis publication-title: J. Gene Med. doi: 10.1002/jgm.1293 – volume: 98 start-page: 4611 year: 2001 ident: B7 article-title: An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.081082098 – volume: 180 start-page: 147 year: 2013 ident: B13 article-title: Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure publication-title: J. Surg. Res. doi: 10.1016/j.jss.2012.11.051 – volume: 137 start-page: 947 year: 2002 ident: B34 article-title: Results of a prospective study of acute liver failure at 17 tertiary Care centers in the United States publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-137-12-200212170-00007 – start-page: 267 volume-title: Adverse drug reactions year: 2010 ident: B16 article-title: Signal transduction pathways involved in drug-induced liver injury doi: 10.1007/978-3-642-00663-0_10 – volume: 17 start-page: 274 year: 2018 ident: B45 article-title: Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions publication-title: Redox Biol. doi: 10.1016/j.redox.2018.04.019 – volume: 332 start-page: 1429 year: 2011 ident: B39 article-title: links autophagy to lysosomal biogenesis publication-title: Science doi: 10.1126/science.1204592 – volume: 91 start-page: 164 year: 2016 ident: B9 article-title: Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2015.12.011 – volume: 9 start-page: e1003330 year: 2013 ident: B33 article-title: IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1003330 – volume: 8 start-page: 997 year: 2017 ident: B35 article-title: Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage publication-title: Food Funct. doi: 10.1039/c7fo00054e – volume: 143 start-page: 1158 year: 2012 ident: B26 article-title: Sterile inflammation in the liver publication-title: Gastroenterology doi: 10.1053/j.gastro.2012.09.008 – volume: 30 start-page: 1280 year: 2010 ident: B43 article-title: Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice publication-title: Liver Int. doi: 10.1111/j.1478-3231.2010.02284.x |
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| Snippet | Cardamonin (CD), a naturally occurring chalcone derived from the
Alpinia
species, has been shown to exert antioxidant and anti-inflammatory activity, but its... Cardamonin (CD), a naturally occurring chalcone derived from the species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in... Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its... |
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| SubjectTerms | acetaminophen acute liver injury autophagy cardamonin NFE2L2 Pharmacology |
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| Title | Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling |
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