Association Between NR3C1 Mutations and Glucocorticoid Resistance in Children With Acute Lymphoblastic Leukemia

• Published in: Frontiers in pharmacology Vol. 12; p. 634956
• Main Authors: Liu, Haiyan, Li, Ziping, Qiu, Fei, Li, Chunjie, Lin, Xiaojing, He, Yingyi, Qian, Maoxiang, Song, Yuanbin, Zhang, Hui
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.03.2021
• Subjects: acute lymphoblastic leukemia; drug resistance; glucocorticoid; glucocorticoid receptor; NR3C1; Pharmacology; glucocorticoid; glucocorticoid receptor; drug resistance; NR3C1; acute lymphoblastic leukemia

Treatment outcomes in children with acute lymphoblastic leukemia (ALL) have been improved substantially, with a cure rate exceeding 80% using conventional therapy. However, the outcome for patients with relapsed/refractory ALL remains unsatisfactory, despite the fact that these patients generally re...