Distinctive modulation of hepcidin in cancer and its therapeutic relevance

• Published in: Frontiers in oncology Vol. 13; p. 1141603
• Main Authors: Lin, Feng, Tuffour, Alex, Hao, Guijie, Peprah, Frank Addai, Huang, Aixia, Zhou, Yang, Zhang, Haiqi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.02.2023
• Subjects: cancer; hepcidin; homeostasis; iron; metabolism; Oncology; therapeutics; homeostasis; iron; hepcidin; therapeutics; cancer; metabolism

Hepcidin, a short peptide synthesized primarily by hepatocytes in response to increased body iron and inflammation, is a crucial iron-regulating factor. Hepcidin regulates intestinal iron absorption and releases iron from macrophages into plasma through a negative iron feedback mechanism. The discov...