Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis

• Published in: Frontiers in immunology Vol. 13; p. 966291
• Main Authors: Li, Chunbo, Liu, Danyang, Yang, Shimin, Hua, Keqin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.12.2022
• Subjects: CD8-Positive T-Lymphocytes; cervical cancer; Ecosystem; Female; Humans; Immunology; metastatic lymph node; Single-Cell Gene Expression Analysis; single-cell sequencing; T-Lymphocytes, Regulatory; tumor heterogeneity; tumor microenvironment; Tumor Microenvironment - genetics; Uterine Cervical Neoplasms; single-cell sequencing; tumor microenvironment; metastatic lymph node; cervical cancer; tumor heterogeneity

Cervical cancer (CC) is one of the most frequent female malignancies worldwide. However, the molecular mechanism of lymph node metastasis in CC remains unclear. In this study, we investigated the transcriptome profile of 51,507 single cells from primary tumors, positive lymph nodes (P-LN), and negat...