The Role of Macrophages in Kidney Fibrosis

• Published in: Frontiers in physiology Vol. 12; p. 705838
• Main Authors: Wang, Xiaoling, Chen, Jianwei, Xu, Jun, Xie, Jun, Harris, David C. H., Zheng, Guoping
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.08.2021
• Subjects: fibrosis; macrophages; Physiology; signaling pathways; TGF-β; Wnt; TGF-β; macrophages; fibrosis; signaling pathways; Wnt

The phenotypic heterogeneity and functional diversity of macrophages confer on them complexed roles in the development and progression of kidney diseases. After kidney injury, bone marrow-derived monocytes are rapidly recruited to the glomerulus and tubulointerstitium. They are activated and differe...