Identification of copper metabolism and cuproptosis-related subtypes for predicting prognosis tumor microenvironment and drug candidates in hepatocellular carcinoma

• Published in: Frontiers in immunology Vol. 13; p. 996308
• Main Authors: Liu, Xianglong, Sun, Bo, Yao, Yiyang, Lai, Linying, Wang, Xueyuan, Xiong, Jie, Zhang, Xiaoan, Jiang, Jie
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.10.2022
• Subjects: Apoptosis; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - genetics; Copper; copper metabolism; CTLA-4 Antigen - genetics; cuproptosis; DNA Copy Number Variations; hepatic carcinoma; Humans; Imatinib Mesylate; Immunology; Liver Neoplasms - drug therapy; Liver Neoplasms - genetics; Methotrexate; Prognosis; Sorafenib; therapy; tumor immune microenvironment; Tumor Microenvironment - genetics; hepatic carcinoma; cuproptosis; tumor immune microenvironment; copper metabolism; prognosis; therapy

Copper (Cu) is an essential element of organisms, which can affect the survival of cells. However, the role of copper metabolism and cuproptosis on hepatic carcinoma is still unclear. In this study, the TCGA database was used as the test set, and the ICGC database and self-built database were used a...