Various Subtypes of EGFR Mutations in Patients With NSCLC Define Genetic, Immunologic Diversity and Possess Different Prognostic Biomarkers

• Published in: Frontiers in immunology Vol. 13; p. 811601
• Main Authors: Lei, Youming, Wang, Kun, Liu, Yinqiang, Wang, Xuming, Xiang, Xudong, Ning, Xiangu, Ding, Wanbao, Duan, Jin, Li, Dingbiao, Zhao, Wei, Li, Yi, Zhang, Fujun, Luo, Xiaoyu, Shi, Yunfei, Wang, Ying, Huang, Depei, Bai, Yuezong, Zhang, Hushan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.02.2022
• Subjects: B7-H1 Antigen - genetics; Biomarkers; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; EGFR - epidermal growth factor receptor; ErbB Receptors - genetics; Humans; immune microenviroment; Immunology; Lung Neoplasms; Mutation; NSCLC; Prognosis; Tumor Microenvironment - genetics; EGFR - epidermal growth factor receptor; immune microenviroment; NSCLC; prognosis; biomarkers

Based on data analysis of 9649 Chinese primary NSCLC patients, we calculated the exact proportion of EGFR subtypes in NSCLC and evaluated the TMB level, PD-L1 expression level and tumor immune microenvironment among different EGFR mutation subtypes. Postoperative follow-up data for 98 patients were...