Activation of the PPARγ Prevents Ferroptosis-Induced Neuronal Loss in Response to Intracerebral Hemorrhage Through Synergistic Actions With the Nrf2

• Published in: Frontiers in pharmacology Vol. 13; p. 869300
• Main Authors: Duan, Chenyang, Jiao, Dian, Wang, Hanbin, Wu, Qiaoli, Men, Weidong, Yan, Hua, Li, Chunhui
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.04.2022
• Subjects: ferroptosis; GPx4; intercerebral haemorrhage; Nrf2; Pharmacology; PPAR γ; primary neuron cell culture; ML385; pioglitazone; ferroptosis; GPx4; Nrf2; primary neuron cell culture; PPAR γ; intercerebral haemorrhage

Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. The long-term effects of ICH-induced intracranial hematoma on patients’ neurological function are unclear. Currently, an effective treatment that significantly reduces the rates of death and d...