Interactions between Fibroblasts and Keratinocytes in Morphogenesis of Dermal Epidermal Junction in a Model of Reconstructed Skin

• Published in: Journal of investigative dermatology Vol. 126; no. 5; pp. 971 - 979
• Main Authors: Marionnet, Claire, Pierrard, Cécile, Vioux-Chagnoleau, Corinne, Sok, Juliette, Asselineau, Daniel, Bernerd, Françoise
• Format: Journal Article
• Language: English
• Published: Danvers, MA Elsevier Inc 01.05.2006; Nature Publishing; Elsevier Limited
• Subjects: Biological and medical sciences; Biomarkers; Cell Adhesion Molecules - analysis; Cell Communication; Cells, Cultured; Collagen - analysis; Collagen - genetics; Dermatology; Epidermis - growth & development; Fibrillin-1; Fibrillins; Fibroblasts - physiology; Humans; Kalinin; Keratinocytes - physiology; Medical sciences; Microfilament Proteins - analysis; Microfilament Proteins - genetics; Morphogenesis; RNA, Messenger - analysis; Skin - growth & development; Tenascin - analysis; Tenascin - genetics; Morphogenesis; Dermoepidermal junction; Dermatology; Interaction; Epidermis; Keratinocyte; Models; Skin; Derm; Fibroblast

De novo dermal epidermal junction morphogenesis was studied in a skin model including dermal fibroblasts and epidermal keratinocytes. Sequential gene expression, protein deposition, and localization of basement membrane zone components were studied during 15 days. The morphogenesis of dermal epiderm...