S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes - Nakagawa, Takayuki; Tanino, Tetsuya; Onishi, Motoyasu; Tofukuji, Soichi; Kanazawa, Takayuki; Ishioka, Yukichi; Itoh, Takeshi; Kugimiya, Akira; Katayama, Kazufumi; Yamamoto, Takuya; Nagira, Morio; Ishii, Ken J. (Frontiers in immunology, 2021)
Keywords: adjuvant; Adjuvants, Vaccine - chemistry; Adjuvants, Vaccine - therapeutic use; Animals; cancer peptide vaccine; Cancer Vaccines - immunology; CD8-Positive T-Lymphocytes - immunology; Cell Differentiation; CpG oligonucleotide; delivery system; Dendritic Cells - immunology; DNA - chemistry; draining lymph node; Female; Humans; Immunization; Immunology; Lung Neoplasms - immunology; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Oligodeoxyribonucleotides - administration & dosage; Oligodeoxyribonucleotides - chemistry; Papillomavirus E7 Proteins - immunology; Sentinel Lymph Node - immunology; Surface-Active Agents - chemistry; Toll-Like Receptor 9 - agonists; Toll-Like Receptor 9 - genetics; Toll-Like Receptor 9 - metabolism; Vaccines, Subunit; CpG oligonucleotide; delivery system; adjuvant; cancer peptide vaccine; draining lymph node