The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial

• Published in: Frontiers in immunology Vol. 12; p. 787797
• Main Authors: Xu, Dengfeng, Feng, Meiyuan, Chu, YiFang, Wang, Shaokang, Shete, Varsha, Tuohy, Kieran M., Liu, Feng, Zhou, Xirui, Kamil, Alison, Pan, Da, Liu, Hechun, Yang, Xian, Yang, Chao, Zhu, Baoli, Lv, Na, Xiong, Qian, Wang, Xin, Sun, Jianqin, Sun, Guiju, Yang, Yuexin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.12.2021
• Subjects: Adult; Avena; Bacteria - genetics; Bacteria - growth & development; Bacteria - metabolism; Beijing; Biomarkers - blood; cholesterol; Dysbiosis; Edible Grain; Fatty Acids, Volatile - blood; Female; Gastrointestinal Microbiome; Humans; Hypercholesterolemia - blood; Hypercholesterolemia - diagnosis; Hypercholesterolemia - diet therapy; Hypercholesterolemia - microbiology; Immunology; Lipids - blood; Male; microbiota; Middle Aged; oat; Oryza; polyphenol; Prebiotics - administration & dosage; short-chain fatty acids; Single-Blind Method; Time Factors; Treatment Outcome; β-glucan; Beijing; microbiota; β-glucan; cholesterol; oat; polyphenol; short-chain fatty acids

Phytochemicals derived from oats are reported to possess a beneficial effect on modulating dyslipidemia, specifically on lowering total and LDL cholesterol. However, deeper insights into its mechanism remain unclear. In this randomized controlled study, we assigned 210 mildly hypercholesterolemic su...