Vitamin D supplementation and endothelial function in vitamin D deficient HIV-infected patients: a randomized placebo-controlled trial

Studies suggest that vitamin D deficiency is a risk factor for cardiovascular disease and diabetes. Vitamin D deficiency is prevalent in HIV patients but the effect of vitamin D supplementation on cardiovascular risk in this population is unknown. We conducted a randomized, double-blind, placebo-con...

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Published inAntiviral therapy Vol. 17; no. 4; pp. 613 - 621
Main Authors LONGENECKER, Chris T, HILEMAN, Corrilynn O, CARMAN, Teresa L, ROSS, Allison C, SEYDAFKAN, Shabnam, BROWN, Todd T, LABBATO, Danielle E, STORER, Norma, TANGPRICHA, Vin, MCCOMSEY, Grace A
Format Journal Article
LanguageEnglish
Published London International Medical Press 01.01.2012
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Abstract Studies suggest that vitamin D deficiency is a risk factor for cardiovascular disease and diabetes. Vitamin D deficiency is prevalent in HIV patients but the effect of vitamin D supplementation on cardiovascular risk in this population is unknown. We conducted a randomized, double-blind, placebo-controlled trial among 45 HIV-infected adults in Cleveland (OH, USA) on stable antiretroviral therapy with durable virological suppression and a baseline serum 25-hydroxyvitamin D level of ≤20 ng/ml. Participants were randomized 2:1 to vitamin D3 4,000 IU daily or placebo for 12 weeks. The primary outcome was a change in flow-mediated brachial artery dilation (FMD). Baseline demographics were similar except for age (vitamin D versus placebo, mean ±sd 47 ±8 versus 40 ±10 years; P=0.009). Both groups had reduced FMD at baseline (median values 2.9% [IQR 1.6-4.8] for vitamin D versus 2.5% [IQR 1.7-6.4] for placebo; P=0.819). Despite an increase in the concentration of serum 25-hydroxyvitamin D from baseline to 12 weeks (5.0 ng/ml [IQR -0.9-7.4] versus -1.9 ng/ml [IQR -4.0-0.1] for vitamin D versus placebo, respectively; P=0.003), there was no difference in FMD change (0.55% [IQR -1.05-2.13] versus 0.29% [IQR -1.61-1.77]; P=0.748). Vitamin D supplementation was associated with a decrease in total and non-high-density lipoprotein cholesterol, and an increase in indices of insulin resistance. Among HIV-infected individuals with vitamin D deficiency, supplementation with 4,000 IU vitamin D3 daily for 12 weeks modestly improved vitamin D status and cholesterol but worsened insulin resistance without change in endothelial function. The mechanisms of resistance to standard doses of vitamin D and the complex role of vitamin D in glucose metabolism in this population require further investigation.
AbstractList BACKGROUNDStudies suggest that vitamin D deficiency is a risk factor for cardiovascular disease and diabetes. Vitamin D deficiency is prevalent in HIV patients but the effect of vitamin D supplementation on cardiovascular risk in this population is unknown. METHODSWe conducted a randomized, double-blind, placebo-controlled trial among 45 HIV-infected adults in Cleveland (OH, USA) on stable antiretroviral therapy with durable virological suppression and a baseline serum 25-hydroxyvitamin D level of ≤20 ng/ml. Participants were randomized 2:1 to vitamin D3 4,000 IU daily or placebo for 12 weeks. The primary outcome was a change in flow-mediated brachial artery dilation (FMD). RESULTSBaseline demographics were similar except for age (vitamin D versus placebo, mean ±sd 47 ±8 versus 40 ±10 years; P=0.009). Both groups had reduced FMD at baseline (median values 2.9% [IQR 1.6-4.8] for vitamin D versus 2.5% [IQR 1.7-6.4] for placebo; P=0.819). Despite an increase in the concentration of serum 25-hydroxyvitamin D from baseline to 12 weeks (5.0 ng/ml [IQR -0.9-7.4] versus -1.9 ng/ml [IQR -4.0-0.1] for vitamin D versus placebo, respectively; P=0.003), there was no difference in FMD change (0.55% [IQR -1.05-2.13] versus 0.29% [IQR -1.61-1.77]; P=0.748). Vitamin D supplementation was associated with a decrease in total and non-high-density lipoprotein cholesterol, and an increase in indices of insulin resistance. CONCLUSIONSAmong HIV-infected individuals with vitamin D deficiency, supplementation with 4,000 IU vitamin D3 daily for 12 weeks modestly improved vitamin D status and cholesterol but worsened insulin resistance without change in endothelial function. The mechanisms of resistance to standard doses of vitamin D and the complex role of vitamin D in glucose metabolism in this population require further investigation.
Studies suggest that vitamin D deficiency is a risk factor for cardiovascular disease and diabetes. Vitamin D deficiency is prevalent in HIV patients but the effect of vitamin D supplementation on cardiovascular risk in this population is unknown. We conducted a randomized, double-blind, placebo-controlled trial among 45 HIV-infected adults in Cleveland (OH, USA) on stable antiretroviral therapy with durable virological suppression and a baseline serum 25-hydroxyvitamin D level of ≤20 ng/ml. Participants were randomized 2:1 to vitamin D3 4,000 IU daily or placebo for 12 weeks. The primary outcome was a change in flow-mediated brachial artery dilation (FMD). Baseline demographics were similar except for age (vitamin D versus placebo, mean ±sd 47 ±8 versus 40 ±10 years; P=0.009). Both groups had reduced FMD at baseline (median values 2.9% [IQR 1.6-4.8] for vitamin D versus 2.5% [IQR 1.7-6.4] for placebo; P=0.819). Despite an increase in the concentration of serum 25-hydroxyvitamin D from baseline to 12 weeks (5.0 ng/ml [IQR -0.9-7.4] versus -1.9 ng/ml [IQR -4.0-0.1] for vitamin D versus placebo, respectively; P=0.003), there was no difference in FMD change (0.55% [IQR -1.05-2.13] versus 0.29% [IQR -1.61-1.77]; P=0.748). Vitamin D supplementation was associated with a decrease in total and non-high-density lipoprotein cholesterol, and an increase in indices of insulin resistance. Among HIV-infected individuals with vitamin D deficiency, supplementation with 4,000 IU vitamin D3 daily for 12 weeks modestly improved vitamin D status and cholesterol but worsened insulin resistance without change in endothelial function. The mechanisms of resistance to standard doses of vitamin D and the complex role of vitamin D in glucose metabolism in this population require further investigation.
Author ROSS, Allison C
SEYDAFKAN, Shabnam
LABBATO, Danielle E
BROWN, Todd T
HILEMAN, Corrilynn O
MCCOMSEY, Grace A
CARMAN, Teresa L
TANGPRICHA, Vin
STORER, Norma
LONGENECKER, Chris T
AuthorAffiliation 2 Case Western Reserve University School of Medicine, Cleveland, OH, USA
8 Atlanta VA Medical Center, Decatur, GA, USA
1 University Hospitals Case Medical Center, Cleveland, OH, USA
3 MetroHealth Medical Center, Cleveland, OH, USA
4 Emory University School of Medicine, Atlanta, GA, USA
5 Children's Healthcare of Atlanta, Atlanta, GA, USA
7 Rainbow Babies and Children's Hospital, Cleveland, OH, USA
6 Johns Hopkins University School of Medicine, Baltimore, MD, USA
AuthorAffiliation_xml – name: 1 University Hospitals Case Medical Center, Cleveland, OH, USA
– name: 7 Rainbow Babies and Children's Hospital, Cleveland, OH, USA
– name: 6 Johns Hopkins University School of Medicine, Baltimore, MD, USA
– name: 2 Case Western Reserve University School of Medicine, Cleveland, OH, USA
– name: 8 Atlanta VA Medical Center, Decatur, GA, USA
– name: 5 Children's Healthcare of Atlanta, Atlanta, GA, USA
– name: 3 MetroHealth Medical Center, Cleveland, OH, USA
– name: 4 Emory University School of Medicine, Atlanta, GA, USA
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  surname: LONGENECKER
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  organization: University Hospitals Case Medical Center, Cleveland, OH, United States
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  surname: LABBATO
  fullname: LABBATO, Danielle E
  organization: University Hospitals Case Medical Center, Cleveland, OH, United States
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  givenname: Norma
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  surname: MCCOMSEY
  fullname: MCCOMSEY, Grace A
  organization: University Hospitals Case Medical Center, Cleveland, OH, United States
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Cites_doi 10.1093/ajcn/87.1.136
10.1016/j.jacc.2005.02.073
10.1097/HJH.0b013e32832f075b
10.1016/S0735-1097(01)01746-6
10.1007/s00125-010-1838-1
10.1007/s11908-010-0144-x
10.1210/jc.2008-1212
10.1097/QAD.0b013e328342fdfd
10.1093/ajcn/77.1.204
10.1161/CIRCULATIONAHA.107.706127
10.1001/archinte.168.11.1174
10.1093/cid/ciq158
10.1093/cid/ciq239
10.1186/1476-9255-5-10
10.1001/archinte.167.16.1730
10.3851/IMP1784
10.1210/jc.2011-0385
10.1038/clpt.2008.165
10.3851/IMP1502
10.1001/archinte.168.12.1340
10.1056/NEJMra070553
10.1016/j.jacc.2008.08.050
10.1089/aid.2009.0267
10.2337/dc10-0633
10.1086/503261
10.1038/ejcn.2011.118
10.1111/j.1464-5491.2007.02360.x
10.1542/peds.2008-0176
10.1097/QAI.0b013e318189a794
10.1007/BF00280883
10.1371/journal.pone.0008770
10.1161/CIRCULATIONAHA.106.652859
10.1210/jc.2010-2704
10.1111/j.1468-1293.2008.00630.x
10.1016/j.cellbi.2006.01.004
10.1172/JCI21867
10.1161/HYPERTENSIONAHA.110.160929
10.1530/EJE-08-0952
10.1097/QAD.0b013e32833c3281
10.1016/j.jacc.2008.04.049
10.1097/QAD.0b013e32833c3251
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Issue 4
Keywords Infection
Immunopathology
Randomization
Vitamin D
Viral disease
AIDS
Supplementation
Immune deficiency
Endothelium
Language English
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References 18175747 - Am J Clin Nutr. 2008 Jan;87(1):136-41
18574092 - Arch Intern Med. 2008 Jun 23;168(12):1340-9
21646368 - J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30
20596692 - Diabetologia. 2010 Oct;53(10):2112-9
15963397 - J Am Coll Cardiol. 2005 Jun 21;45(12):1987-93
18180395 - Circulation. 2008 Jan 29;117(4):503-11
21178753 - AIDS. 2011 Feb 20;25(4):525-9
17846391 - Arch Intern Med. 2007 Sep 10;167(16):1730-7
18754003 - Clin Pharmacol Ther. 2009 Feb;85(2):198-203
19055985 - J Am Coll Cardiol. 2008 Dec 9;52(24):1949-56
16549374 - Cell Biol Int. 2006 Apr;30(4):365-75
12499343 - Am J Clin Nutr. 2003 Jan;77(1):204-10
20854196 - AIDS Res Hum Retroviruses. 2011 Jan;27(1):29-34
21118827 - J Clin Endocrinol Metab. 2011 Jan;96(1):53-8
19587609 - J Hypertens. 2009 Oct;27(10):1948-54
19584181 - J Clin Endocrinol Metab. 2009 Oct;94(10):4023-30
20516561 - Antivir Ther. 2010;15(3):425-9
21115878 - Hypertension. 2011 Jan;57(1):63-9
3899825 - Diabetologia. 1985 Jul;28(7):412-9
20588161 - AIDS. 2010 Jul 31;24(12):1923-8
18541825 - Arch Intern Med. 2008 Jun 9;168(11):1174-80
18279409 - Diabet Med. 2008 Mar;25(3):320-5
18652680 - J Inflamm (Lond). 2008 Jul 24;5:10
19289535 - Eur J Endocrinol. 2009 Jun;160(6):965-71
21685543 - Antivir Ther. 2011;16(4):555-63
15630458 - J Clin Invest. 2005 Jan;115(1):177-86
20098738 - PLoS One. 2010;5(1):e8770
18754805 - HIV Med. 2008 Oct;9(9):771-9
11788217 - J Am Coll Cardiol. 2002 Jan 16;39(2):257-65
18687253 - J Am Coll Cardiol. 2008 Aug 12;52(7):569-76
19117833 - Pediatrics. 2009 Jan;123(1):e121-6
17353456 - Circulation. 2007 Mar 13;115(10):1285-95
21217186 - Clin Infect Dis. 2011 Feb 1;52(3):396-405
20613460 - AIDS. 2010 Jul 31;24(12):1958-61
17634462 - N Engl J Med. 2007 Jul 19;357(3):266-81
18989230 - J Acquir Immune Defic Syndr. 2008 Dec 15;49(5):499-506
21273298 - Clin Infect Dis. 2011 Apr 1;52(7):941-4
20664016 - Diabetes Care. 2010 Oct;33(10):2244-9
21731035 - Eur J Clin Nutr. 2011 Sep;65(9):1005-15
21308459 - Curr Infect Dis Rep. 2011 Feb;13(1):83-93
16586393 - Clin Infect Dis. 2006 May 1;42(9):1325-32
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bibr8-IMP1983
bibr34-IMP1983
bibr17-IMP1983
bibr31-IMP1983
bibr18-IMP1983
bibr32-IMP1983
bibr16-IMP1983
Fox J. (bibr26-IMP1983) 2010; 26
bibr30-IMP1983
bibr9-IMP1983
bibr19-IMP1983
bibr15-IMP1983
bibr14-IMP1983
bibr28-IMP1983
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bibr43-IMP1983
bibr4-IMP1983
bibr12-IMP1983
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bibr27-IMP1983
bibr41-IMP1983
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  doi: 10.1093/ajcn/87.1.136
– ident: bibr33-IMP1983
  doi: 10.1016/j.jacc.2005.02.073
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  doi: 10.1097/HJH.0b013e32832f075b
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  doi: 10.1016/S0735-1097(01)01746-6
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  doi: 10.1007/s00125-010-1838-1
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  doi: 10.1007/s11908-010-0144-x
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  doi: 10.1210/jc.2008-1212
– ident: bibr17-IMP1983
  doi: 10.1097/QAD.0b013e328342fdfd
– ident: bibr34-IMP1983
  doi: 10.1093/ajcn/77.1.204
– ident: bibr4-IMP1983
  doi: 10.1161/CIRCULATIONAHA.107.706127
– ident: bibr5-IMP1983
  doi: 10.1001/archinte.168.11.1174
– ident: bibr22-IMP1983
  doi: 10.1093/cid/ciq158
– ident: bibr19-IMP1983
  doi: 10.1093/cid/ciq239
– ident: bibr43-IMP1983
  doi: 10.1186/1476-9255-5-10
– ident: bibr7-IMP1983
  doi: 10.1001/archinte.167.16.1730
– ident: bibr18-IMP1983
  doi: 10.3851/IMP1784
– ident: bibr21-IMP1983
  doi: 10.1210/jc.2011-0385
– ident: bibr39-IMP1983
  doi: 10.1038/clpt.2008.165
– ident: bibr24-IMP1983
  doi: 10.3851/IMP1502
– ident: bibr6-IMP1983
  doi: 10.1001/archinte.168.12.1340
– ident: bibr30-IMP1983
– ident: bibr1-IMP1983
  doi: 10.1056/NEJMra070553
– ident: bibr2-IMP1983
  doi: 10.1016/j.jacc.2008.08.050
– volume: 26
  start-page: 1
  year: 2010
  ident: bibr26-IMP1983
  publication-title: AIDS Res Hum Retroviruses
  doi: 10.1089/aid.2009.0267
  contributor:
    fullname: Fox J.
– ident: bibr42-IMP1983
  doi: 10.2337/dc10-0633
– ident: bibr31-IMP1983
  doi: 10.1086/503261
– ident: bibr37-IMP1983
  doi: 10.1038/ejcn.2011.118
– ident: bibr10-IMP1983
  doi: 10.1111/j.1464-5491.2007.02360.x
– ident: bibr20-IMP1983
  doi: 10.1542/peds.2008-0176
– ident: bibr41-IMP1983
  doi: 10.1097/QAI.0b013e318189a794
– ident: bibr27-IMP1983
  doi: 10.1007/BF00280883
– ident: bibr25-IMP1983
– ident: bibr16-IMP1983
  doi: 10.1371/journal.pone.0008770
– ident: bibr9-IMP1983
  doi: 10.1161/CIRCULATIONAHA.106.652859
– ident: bibr8-IMP1983
  doi: 10.1210/jc.2010-2704
– ident: bibr35-IMP1983
  doi: 10.1111/j.1468-1293.2008.00630.x
– ident: bibr14-IMP1983
  doi: 10.1016/j.cellbi.2006.01.004
– ident: bibr36-IMP1983
  doi: 10.1172/JCI21867
– ident: bibr13-IMP1983
  doi: 10.1161/HYPERTENSIONAHA.110.160929
– ident: bibr40-IMP1983
  doi: 10.1530/EJE-08-0952
– ident: bibr23-IMP1983
  doi: 10.1097/QAD.0b013e32833c3281
– ident: bibr28-IMP1983
  doi: 10.1016/j.jacc.2008.04.049
– ident: bibr32-IMP1983
  doi: 10.1097/QAD.0b013e32833c3251
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Snippet Studies suggest that vitamin D deficiency is a risk factor for cardiovascular disease and diabetes. Vitamin D deficiency is prevalent in HIV patients but the...
BACKGROUNDStudies suggest that vitamin D deficiency is a risk factor for cardiovascular disease and diabetes. Vitamin D deficiency is prevalent in HIV patients...
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SubjectTerms Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Biomarkers
Case-Control Studies
Dietary Supplements
HIV Infections - complications
HIV Infections - drug therapy
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Medical sciences
Pharmacology. Drug treatments
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Vitamin D - therapeutic use
Vitamin D Deficiency - complications
Vitamin D Deficiency - drug therapy
Title Vitamin D supplementation and endothelial function in vitamin D deficient HIV-infected patients: a randomized placebo-controlled trial
URI https://www.ncbi.nlm.nih.gov/pubmed/22293363
https://search.proquest.com/docview/1017760441
https://pubmed.ncbi.nlm.nih.gov/PMC3898848
Volume 17
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