Contribution of Dysregulated B-Cells and IgE Antibody Responses to Multiple Sclerosis

• Published in: Frontiers in immunology Vol. 13; p. 900117
• Main Authors: Seals, Malik R., Moran, Monica M., Leavenworth, Jonathan D., Leavenworth, Jianmei W.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.06.2022
• Subjects: Animals; Antibody Formation; B-cells; B-Lymphocytes; Encephalomyelitis, Autoimmune, Experimental; humoral antibody response; IgE; Immunoglobulin E; Immunology; macrophage; Mice; microglia; Multiple Sclerosis; neuroinflammation; humoral antibody response; B-cells; experimental autoimmune encephalomyelitis; neuroinflammation; IgE; multiple sclerosis; macrophage; microglia
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2022.900117

Multiple sclerosis (MS), a debilitating autoimmune inflammatory disease that affects the brain and spinal cord, causes demyelination of neurons, axonal damage, and neurodegeneration. MS and the murine experimental autoimmune encephalomyelitis (EAE) model have been viewed mainly as T-cell-mediated di...