Subcellular antigen localization in commensal E. coli is critical for T cell activation and induction of specific tolerance

• Published in: Mucosal immunology Vol. 12; no. 1; pp. 97 - 107
• Main Authors: Bennek, Eveline, Mandić, Ana D., Verdier, Julien, Roubrocks, Silvia, Pabst, Oliver, Van Best, Niels, Benz, Inga, Kufer, Thomas, Trautwein, Christian, Sellge, Gernot
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.01.2019; Nature Publishing Group US; Elsevier Limited
• Subjects: Administration, Oral; Allergology; Animals; Antibodies; Antigens; Antigens, Bacterial - genetics; Antigens, Bacterial - immunology; Biomedical and Life Sciences; Biomedicine; CD4 antigen; Cell activation; Cells, Cultured; Colonization; Cytoplasm; Dendritic cells; Digestive system; E coli; Escherichia coli - physiology; Female; Forkhead Transcription Factors - metabolism; Foxp3 protein; Gastroenterology; Gastrointestinal Microbiome - physiology; Gastrointestinal tract; Homeostasis; Immune Tolerance; Immunological tolerance; Immunology; Intestinal microflora; Intestine; Intracellular Space; Localization; Lymphocyte Activation; Lymphocytes T; Membrane proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbiota; Microorganisms, Genetically-Modified; Ovalbumin; Ovalbumin - genetics; Ovalbumin - immunology; Peptides - genetics; Peptides - immunology; Symbiosis; T-Lymphocytes, Regulatory - immunology

Oral tolerance to soluble antigens is critically important for the maintenance of immunological homeostasis in the gut. The mechanisms of tolerance induction to antigens of the gut microbiota are still less well understood. Here, we investigate whether the subcellular localization of antigens within...