The Roles of Neutrophils in the Pathogenesis of Liver Diseases

Neutrophils are the largest population of circulating leukocytes and the first responder against invading pathogens or other danger signals. Sophisticated machineries help them play critical roles in immunity and inflammation, including phagocytosis, superoxide production, cytokine and chemokine pro...

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Published inFrontiers in immunology Vol. 12; p. 625472
Main Authors Tang, Jiaojiao, Yan, Zijun, Feng, Qiyu, Yu, Lexing, Wang, Hongyang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.03.2021
Subjects
alcoholic liver disease
hepatocellular carcinoma
Immunology
liver regeneration
neutrophils
non-aloholic liver disease
non-aloholic liver disease
alcoholic liver disease
liver regeneration
neutrophils
hepatocellular carcinoma
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Abstract Neutrophils are the largest population of circulating leukocytes and the first responder against invading pathogens or other danger signals. Sophisticated machineries help them play critical roles in immunity and inflammation, including phagocytosis, superoxide production, cytokine and chemokine production, degranulation, and formation of neutrophil extracellular traps (NETs). After maturation and release from the bone marrow, neutrophils migrate to inflamed tissues in response to many stimuli. Increasing evidences indicate that neutrophils are critically involved in the pathogenesis of liver diseases, including liver cancer, thus making them promising target for the treatment of liver diseases. Here, we would like to provide the latest finding about the role of neutrophils in liver diseases and discuss the potentiality of neutrophils as target for liver diseases.
AbstractList Neutrophils are the largest population of circulating leukocytes and the first responder against invading pathogens or other danger signals. Sophisticated machineries help them play critical roles in immunity and inflammation, including phagocytosis, superoxide production, cytokine and chemokine production, degranulation, and formation of neutrophil extracellular traps (NETs). After maturation and release from the bone marrow, neutrophils migrate to inflamed tissues in response to many stimuli. Increasing evidences indicate that neutrophils are critically involved in the pathogenesis of liver diseases, including liver cancer, thus making them promising target for the treatment of liver diseases. Here, we would like to provide the latest finding about the role of neutrophils in liver diseases and discuss the potentiality of neutrophils as target for liver diseases.Neutrophils are the largest population of circulating leukocytes and the first responder against invading pathogens or other danger signals. Sophisticated machineries help them play critical roles in immunity and inflammation, including phagocytosis, superoxide production, cytokine and chemokine production, degranulation, and formation of neutrophil extracellular traps (NETs). After maturation and release from the bone marrow, neutrophils migrate to inflamed tissues in response to many stimuli. Increasing evidences indicate that neutrophils are critically involved in the pathogenesis of liver diseases, including liver cancer, thus making them promising target for the treatment of liver diseases. Here, we would like to provide the latest finding about the role of neutrophils in liver diseases and discuss the potentiality of neutrophils as target for liver diseases.
Neutrophils are the largest population of circulating leukocytes and the first responder against invading pathogens or other danger signals. Sophisticated machineries help them play critical roles in immunity and inflammation, including phagocytosis, superoxide production, cytokine and chemokine production, degranulation, and formation of neutrophil extracellular traps (NETs). After maturation and release from the bone marrow, neutrophils migrate to inflamed tissues in response to many stimuli. Increasing evidences indicate that neutrophils are critically involved in the pathogenesis of liver diseases, including liver cancer, thus making them promising target for the treatment of liver diseases. Here, we would like to provide the latest finding about the role of neutrophils in liver diseases and discuss the potentiality of neutrophils as target for liver diseases.
Author Yan, Zijun
Yu, Lexing
Wang, Hongyang
Feng, Qiyu
Tang, Jiaojiao
AuthorAffiliation 1 Division of Life Sciences and Medicine, Cancer Research Center, The First Affiliated Hospital of University of Science and Technology of China , Hefei , China
4 National Center for Liver Cancer , Shanghai , China
3 Graduate Management Unit, Shanghai Changhai Hospital, Second Military Medical University , Shanghai , China
2 International Cooperation Laboratory on Signal Transduction, Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer, Shanghai Key Laboratory of Hepato-Biliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital , Shanghai , China
AuthorAffiliation_xml – name: 4 National Center for Liver Cancer , Shanghai , China
– name: 1 Division of Life Sciences and Medicine, Cancer Research Center, The First Affiliated Hospital of University of Science and Technology of China , Hefei , China
– name: 2 International Cooperation Laboratory on Signal Transduction, Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer, Shanghai Key Laboratory of Hepato-Biliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital , Shanghai , China
– name: 3 Graduate Management Unit, Shanghai Changhai Hospital, Second Military Medical University , Shanghai , China
Author_xml – sequence: 1
  givenname: Jiaojiao
  surname: Tang
  fullname: Tang, Jiaojiao
– sequence: 2
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  givenname: Lexing
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  fullname: Yu, Lexing
– sequence: 5
  givenname: Hongyang
  surname: Wang
  fullname: Wang, Hongyang
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33763069$$D View this record in MEDLINE/PubMed
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Keywords non-aloholic liver disease
alcoholic liver disease
liver regeneration
neutrophils
hepatocellular carcinoma
Language English
License Copyright © 2021 Tang, Yan, Feng, Yu and Wang.
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This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Edited by: Markus H. Hoffmann, University of Erlangen Nuremberg, Germany
Reviewed by: Irina Miralda, Seattle Children's Research Institute, United States; Yi Zhao, Sichuan University, China
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Snippet Neutrophils are the largest population of circulating leukocytes and the first responder against invading pathogens or other danger signals. Sophisticated...
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SubjectTerms alcoholic liver disease
hepatocellular carcinoma
Immunology
liver regeneration
neutrophils
non-aloholic liver disease
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Title The Roles of Neutrophils in the Pathogenesis of Liver Diseases
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