Nuclear Factor Erythroid 2 Related Factor 2 Activator JC-5411 Inhibits Atherosclerosis Through Suppression of Inflammation and Regulation of Lipid Metabolism

• Published in: Frontiers in pharmacology Vol. 11; p. 532568
• Main Authors: Jiang, Xinhai, Li, Yining, Wang, Weizhi, Han, Xiaowan, Han, Jiangxue, Chen, Mingzhu, Zhang, Jing, Wang, Chenyin, Li, Shunwang, Luo, Jinque, Wang, Xiao, Xu, Yang, Xu, Yanni, Cheng, Jingcai, Si, Shuyi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.11.2020
• Subjects: atherosclerosis; inflammation; JC-5411; nuclear factor erythroid 2-related factor 2; Pharmacology; Phenethyl isothiocyanate; atherosclerosis; Phenethyl isothiocyanate; inflammation; nuclear factor erythroid 2-related factor 2; JC-5411

Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and the underlying mechanisms of JC-5411 (Phenethyl isothiocyanate formulation) in vitro and in vivo . Luciferase reporter assay showed that JC-5411 inc...