Transcriptional and Histochemical Signatures of Bone Marrow Mononuclear Cell-Mediated Resolution of Synovitis

• Published in: Frontiers in immunology Vol. 12; p. 734322
• Main Authors: Menarim, Bruno C, El-Sheikh Ali, Hossam, Loux, Shavahn C, Scoggin, Kirsten E, Kalbfleisch, Theodore S, MacLeod, James N, Dahlgren, Linda A
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.12.2021
• Subjects: Animals; arthritis; Bone Marrow Cells - immunology; Carpal Joints - immunology; Disease Models, Animal; Female; Gene Expression Regulation; Gene Regulatory Networks; Genomics - methods; Horses; Immunology; joint therapy; Leukocytes, Mononuclear - immunology; Lipopolysaccharides - adverse effects; macrophage; Macrophages - immunology; Male; mevalonate pathway; Osteoarthritis - complications; Osteoarthritis - genetics; Osteoarthritis - immunology; oxidative stress; Synovial Fluid - immunology; Synovitis - chemically induced; Synovitis - complications; Synovitis - genetics; Synovitis - immunology; Transcriptome - genetics; joint therapy; macrophage; mevalonate pathway; arthritis; oxidative stress

Osteoarthritis (OA) may result from impaired ability of synovial macrophages to resolve joint inflammation. Increasing macrophage counts in inflamed joints through injection with bone marrow mononuclear cells (BMNC) induces lasting resolution of synovial inflammation. To uncover mechanisms by which...