Single-cell transcriptomic analysis of decidual immune cell landscape in the occurrence of adverse pregnancy outcomes induced by Toxoplasma gondii infection

• Published in: Parasites & vectors Vol. 17; no. 1; p. 213
• Main Authors: Fu, Tianyi, Wang, Xiaohui, Zhao, Xiaoyue, Jiang, Yuzhu, Liu, Xianbing, Zhang, Haixia, Ren, Yushan, Li, Zhidan, Hu, Xuemei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.05.2024; BMC
• Subjects: Abnormal pregnancy; Analysis; Bacterial infections; Decidua - immunology; Decidua - parasitology; Decidual immune cell; Diagnosis; Female; Gene Expression Profiling; Genetic aspects; Health aspects; Humans; Killer Cells, Natural - immunology; Macrophages - immunology; Macrophages - parasitology; Maternal–fetal tolerance; Pregnancy; Pregnancy Outcome; Risk factors; Single-Cell Analysis; Single-cell transcriptomic; T-Lymphocytes - immunology; Toxoplasma; Toxoplasma - immunology; Toxoplasma gondii; Toxoplasmosis - immunology; Toxoplasmosis - parasitology; Transcription factors; Transcriptome; China; Decidual immune cell; Maternal–fetal tolerance; Toxoplasma gondii; Abnormal pregnancy; Single-cell transcriptomic

Toxoplasma gondii is an obligate intracellular parasite that can lead to adverse pregnancy outcomes, particularly in early pregnancy. Previous studies have illustrated the landscape of decidual immune cells. However, the landscape of decidual immune cells in the maternal-fetal microenvironment durin...