Developmental exposure to indoor flame retardants and hypothalamic molecular signatures: Sex-dependent reprogramming of lipid homeostasis

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 997304
• Main Authors: Kozlova, Elena V, Denys, Maximillian E, Benedum, Jonathan, Valdez, Matthew C, Enriquez, Dave, Bishay, Anthony E, Chinthirla, Bhuvaneswari D, Truong, Edward, Krum, Julia M, DiPatrizio, Nicholas V, Deol, Poonamjot, Martins-Green, Manuela, Curras-Collazo, Margarita C
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.09.2022
• Subjects: Adiponectin; Agouti-Related Protein; Animals; Cholesterol; Corn Oil; Endocrine Disruptors - toxicity; endocrine-disrupting chemical (EDC); Endocrinology; Environmental Pollutants - toxicity; fatty liver; Female; Flame Retardants - toxicity; Halogenated Diphenyl Ethers - toxicity; Homeostasis; Leptin; leptin - adiponectin; Male; maternal; metabolic syndrome & type II diabetes; Mice; Mice, Inbred C57BL; Organophosphates; Persistent Organic Pollutants; polybrominated diphenyl ethers (PBDEs); Polychlorinated Biphenyls; Pregnancy; Sex Factors; Triglycerides; leptin - adiponectin; polybrominated diphenyl ethers (PBDEs); dyslipidemia (DLP); endocrine-disrupting chemical (EDC); fatty liver; metabolic syndrome & type II diabetes; hypothalamus; maternal

Polybrominated diphenyl ethers (PBDEs) are a class of flame-retardant organohalogen pollutants that act as endocrine/neuroendocrine disrupting chemicals (EDCs). In humans, exposure to brominated flame retardants (BFR) or other environmentally persistent organic pollutants (POPs) such as polychlorina...