Developmental exposure to indoor flame retardants and hypothalamic molecular signatures: Sex-dependent reprogramming of lipid homeostasis
Polybrominated diphenyl ethers (PBDEs) are a class of flame-retardant organohalogen pollutants that act as endocrine/neuroendocrine disrupting chemicals (EDCs). In humans, exposure to brominated flame retardants (BFR) or other environmentally persistent organic pollutants (POPs) such as polychlorina...
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| Published in | Frontiers in endocrinology (Lausanne) Vol. 13; p. 997304 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
30.09.2022
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| Abstract | Polybrominated diphenyl ethers (PBDEs) are a class of flame-retardant organohalogen pollutants that act as endocrine/neuroendocrine disrupting chemicals (EDCs). In humans, exposure to brominated flame retardants (BFR) or other environmentally persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and novel organophosphate flame retardants has been associated with increasing trends of diabetes and metabolic disease. However, the effects of PBDEs on metabolic processes and their associated sex-dependent features are poorly understood. The metabolic-disrupting effects of perinatal exposure to industrial penta-PBDE mixture, DE-71, on male and female progeny of C57BL/6N mouse dams were examined in adulthood. Dams were exposed to environmentally relevant doses of PBDEs daily for 10 weeks (
): 0.1 (L-DE-71) and 0.4 mg/kg/d (H-DE-71) and offspring parameters were compared to corn oil vehicle controls (VEH/CON). The following lipid metabolism indices were measured: plasma cholesterol, triglycerides, adiponectin, leptin, and liver lipids. L-DE-71 female offspring were particularly affected, showing hypercholesterolemia, elevated liver lipids and fasting plasma leptin as compared to same-sex VEH/CON, while L- and H-DE-71 male F1 only showed reduced plasma adiponectin. Using the quantitative Folch method, we found that mean liver lipid content was significantly elevated in L-DE-71 female offspring compared to controls. Oil Red O staining revealed fatty liver in female offspring and dams. General measures of adiposity, body weight, white and brown adipose tissue (BAT), and lean and fat mass were weighed or measured using EchoMRI. DE-71 did not produce abnormal adiposity, but decreased BAT depots in L-DE-71 females and males relative to same-sex VEH/CON. To begin to address potential central mechanisms of deregulated lipid metabolism, we used RT-qPCR to quantitate expression of hypothalamic genes in energy-regulating circuits that control lipid homeostasis. Both doses of DE-71 sex-dependently downregulated hypothalamic expression of
,
,
,
,
in female offspring while H-DE-71 downregulated
in exposed females relative to VEH/CON. In contrast, exposed male offspring displayed upregulated
and
. Intestinal barrier integrity was measured using FITC-dextran since it can lead to systemic inflammation that leads to liver damage and metabolic disease, but was not affected by DE-71 exposure. These findings indicate that maternal transfer of PBDEs disproportionately endangers female offspring to lipid metabolic reprogramming that may exaggerate risk for adult metabolic disease. |
|---|---|
| AbstractList | Polybrominated diphenyl ethers (PBDEs) are a class of flame-retardant organohalogen pollutants that act as endocrine/neuroendocrine disrupting chemicals (EDCs). In humans, exposure to brominated flame retardants (BFR) or other environmentally persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and novel organophosphate flame retardants has been associated with increasing trends of diabetes and metabolic disease. However, the effects of PBDEs on metabolic processes and their associated sex-dependent features are poorly understood. The metabolic-disrupting effects of perinatal exposure to industrial penta-PBDE mixture, DE-71, on male and female progeny of C57BL/6N mouse dams were examined in adulthood. Dams were exposed to environmentally relevant doses of PBDEs daily for 10 weeks (p.o.): 0.1 (L-DE-71) and 0.4 mg/kg/d (H-DE-71) and offspring parameters were compared to corn oil vehicle controls (VEH/CON). The following lipid metabolism indices were measured: plasma cholesterol, triglycerides, adiponectin, leptin, and liver lipids. L-DE-71 female offspring were particularly affected, showing hypercholesterolemia, elevated liver lipids and fasting plasma leptin as compared to same-sex VEH/CON, while L- and H-DE-71 male F1 only showed reduced plasma adiponectin. Using the quantitative Folch method, we found that mean liver lipid content was significantly elevated in L-DE-71 female offspring compared to controls. Oil Red O staining revealed fatty liver in female offspring and dams. General measures of adiposity, body weight, white and brown adipose tissue (BAT), and lean and fat mass were weighed or measured using EchoMRI. DE-71 did not produce abnormal adiposity, but decreased BAT depots in L-DE-71 females and males relative to same-sex VEH/CON. To begin to address potential central mechanisms of deregulated lipid metabolism, we used RT-qPCR to quantitate expression of hypothalamic genes in energy-regulating circuits that control lipid homeostasis. Both doses of DE-71 sex-dependently downregulated hypothalamic expression of Lepr, Stat3, Mc4r, Agrp, Gshr in female offspring while H-DE-71 downregulated Npy in exposed females relative to VEH/CON. In contrast, exposed male offspring displayed upregulated Stat3 and Mc4r. Intestinal barrier integrity was measured using FITC-dextran since it can lead to systemic inflammation that leads to liver damage and metabolic disease, but was not affected by DE-71 exposure. These findings indicate that maternal transfer of PBDEs disproportionately endangers female offspring to lipid metabolic reprogramming that may exaggerate risk for adult metabolic disease. Polybrominated diphenyl ethers (PBDEs) are a class of flame-retardant organohalogen pollutants that act as endocrine/neuroendocrine disrupting chemicals (EDCs). In humans, exposure to brominated flame retardants (BFR) or other environmentally persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and novel organophosphate flame retardants has been associated with increasing trends of diabetes and metabolic disease. However, the effects of PBDEs on metabolic processes and their associated sex-dependent features are poorly understood. The metabolic-disrupting effects of perinatal exposure to industrial penta-PBDE mixture, DE-71, on male and female progeny of C57BL/6N mouse dams were examined in adulthood. Dams were exposed to environmentally relevant doses of PBDEs daily for 10 weeks ( p.o. ): 0.1 (L-DE-71) and 0.4 mg/kg/d (H-DE-71) and offspring parameters were compared to corn oil vehicle controls (VEH/CON). The following lipid metabolism indices were measured: plasma cholesterol, triglycerides, adiponectin, leptin, and liver lipids. L-DE-71 female offspring were particularly affected, showing hypercholesterolemia, elevated liver lipids and fasting plasma leptin as compared to same-sex VEH/CON, while L- and H-DE-71 male F1 only showed reduced plasma adiponectin. Using the quantitative Folch method, we found that mean liver lipid content was significantly elevated in L-DE-71 female offspring compared to controls. Oil Red O staining revealed fatty liver in female offspring and dams. General measures of adiposity, body weight, white and brown adipose tissue (BAT), and lean and fat mass were weighed or measured using EchoMRI. DE-71 did not produce abnormal adiposity, but decreased BAT depots in L-DE-71 females and males relative to same-sex VEH/CON. To begin to address potential central mechanisms of deregulated lipid metabolism, we used RT-qPCR to quantitate expression of hypothalamic genes in energy-regulating circuits that control lipid homeostasis. Both doses of DE-71 sex-dependently downregulated hypothalamic expression of Lepr , Stat3 , Mc4r , Agrp , Gshr in female offspring while H-DE-71 downregulated Npy in exposed females relative to VEH/CON. In contrast, exposed male offspring displayed upregulated Stat3 and Mc4r . Intestinal barrier integrity was measured using FITC-dextran since it can lead to systemic inflammation that leads to liver damage and metabolic disease, but was not affected by DE-71 exposure. These findings indicate that maternal transfer of PBDEs disproportionately endangers female offspring to lipid metabolic reprogramming that may exaggerate risk for adult metabolic disease. Polybrominated diphenyl ethers (PBDEs) are a class of flame-retardant organohalogen pollutants that act as endocrine/neuroendocrine disrupting chemicals (EDCs). In humans, exposure to brominated flame retardants (BFR) or other environmentally persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and novel organophosphate flame retardants has been associated with increasing trends of diabetes and metabolic disease. However, the effects of PBDEs on metabolic processes and their associated sex-dependent features are poorly understood. The metabolic-disrupting effects of perinatal exposure to industrial penta-PBDE mixture, DE-71, on male and female progeny of C57BL/6N mouse dams were examined in adulthood. Dams were exposed to environmentally relevant doses of PBDEs daily for 10 weeks ( ): 0.1 (L-DE-71) and 0.4 mg/kg/d (H-DE-71) and offspring parameters were compared to corn oil vehicle controls (VEH/CON). The following lipid metabolism indices were measured: plasma cholesterol, triglycerides, adiponectin, leptin, and liver lipids. L-DE-71 female offspring were particularly affected, showing hypercholesterolemia, elevated liver lipids and fasting plasma leptin as compared to same-sex VEH/CON, while L- and H-DE-71 male F1 only showed reduced plasma adiponectin. Using the quantitative Folch method, we found that mean liver lipid content was significantly elevated in L-DE-71 female offspring compared to controls. Oil Red O staining revealed fatty liver in female offspring and dams. General measures of adiposity, body weight, white and brown adipose tissue (BAT), and lean and fat mass were weighed or measured using EchoMRI. DE-71 did not produce abnormal adiposity, but decreased BAT depots in L-DE-71 females and males relative to same-sex VEH/CON. To begin to address potential central mechanisms of deregulated lipid metabolism, we used RT-qPCR to quantitate expression of hypothalamic genes in energy-regulating circuits that control lipid homeostasis. Both doses of DE-71 sex-dependently downregulated hypothalamic expression of , , , , in female offspring while H-DE-71 downregulated in exposed females relative to VEH/CON. In contrast, exposed male offspring displayed upregulated and . Intestinal barrier integrity was measured using FITC-dextran since it can lead to systemic inflammation that leads to liver damage and metabolic disease, but was not affected by DE-71 exposure. These findings indicate that maternal transfer of PBDEs disproportionately endangers female offspring to lipid metabolic reprogramming that may exaggerate risk for adult metabolic disease. |
| Author | Chinthirla, Bhuvaneswari D Truong, Edward DiPatrizio, Nicholas V Bishay, Anthony E Valdez, Matthew C Deol, Poonamjot Kozlova, Elena V Denys, Maximillian E Enriquez, Dave Martins-Green, Manuela Benedum, Jonathan Curras-Collazo, Margarita C Krum, Julia M |
| AuthorAffiliation | 2 Neuroscience Graduate Program, University of California, Riverside , Riverside, CA , United States 3 Biomedical Sciences, School of Medicine, University of California, Riverside , Riverside, CA , United States 1 Department of Molecular, Cell & Systems Biology, University of California, Riverside , Riverside, CA , United States |
| AuthorAffiliation_xml | – name: 1 Department of Molecular, Cell & Systems Biology, University of California, Riverside , Riverside, CA , United States – name: 2 Neuroscience Graduate Program, University of California, Riverside , Riverside, CA , United States – name: 3 Biomedical Sciences, School of Medicine, University of California, Riverside , Riverside, CA , United States |
| Author_xml | – sequence: 1 givenname: Elena V surname: Kozlova fullname: Kozlova, Elena V organization: Neuroscience Graduate Program, University of California, Riverside, Riverside, CA, United States – sequence: 2 givenname: Maximillian E surname: Denys fullname: Denys, Maximillian E organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States – sequence: 3 givenname: Jonathan surname: Benedum fullname: Benedum, Jonathan organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States – sequence: 4 givenname: Matthew C surname: Valdez fullname: Valdez, Matthew C organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States – sequence: 5 givenname: Dave surname: Enriquez fullname: Enriquez, Dave organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States – sequence: 6 givenname: Anthony E surname: Bishay fullname: Bishay, Anthony E organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States – sequence: 7 givenname: Bhuvaneswari D surname: Chinthirla fullname: Chinthirla, Bhuvaneswari D organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States – sequence: 8 givenname: Edward surname: Truong fullname: Truong, Edward organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States – sequence: 9 givenname: Julia M surname: Krum fullname: Krum, Julia M organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States – sequence: 10 givenname: Nicholas V surname: DiPatrizio fullname: DiPatrizio, Nicholas V organization: Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United States – sequence: 11 givenname: Poonamjot surname: Deol fullname: Deol, Poonamjot organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States – sequence: 12 givenname: Manuela surname: Martins-Green fullname: Martins-Green, Manuela organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States – sequence: 13 givenname: Margarita C surname: Curras-Collazo fullname: Curras-Collazo, Margarita C organization: Department of Molecular, Cell & Systems Biology, University of California, Riverside, Riverside, CA, United States |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36277707$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1093_toxsci_kfae047 crossref_primary_10_3390_antiox12101804 crossref_primary_10_1016_j_fbio_2024_103777 crossref_primary_10_1016_j_envpol_2024_123966 crossref_primary_10_7717_peerj_15639 crossref_primary_10_3389_fendo_2023_1049708 crossref_primary_10_1093_toxsci_kfad056 |
| Cites_doi | 10.1016/j.envint.2014.09.006 10.1021/acs.est.8b07032 10.1002/hep.30626 10.1111/j.1872-034X.2012.01031.x 10.1053/j.gastro.2020.01.052 10.1289/ehp.1408417 10.1038/oby.2004.20 10.1210/en.2003-0452 10.1016/j.brainres.2007.04.006 10.1126/science.135.3508.1071 10.1021/acs.est.6b04696 10.2217/epi-2019-0315 10.1007/s11154-007-9049-x 10.1177/0192623312468517 10.1021/acs.chemrestox.5b00208 10.4103/2230-8210.163172 10.1210/er.2011-1050 10.1016/j.scitotenv.2019.03.201 10.1038/385165a0 10.1007/BF00316069 10.1161/CIRCULATIONAHA.107.741645 10.1016/j.lfs.2021.119538 10.1189/jlb.3RU0115-021R 10.1007/s11011-015-9678-9 10.1007/s00204-018-2292-y 10.1093/toxsci/68.2.451 10.3389/fendo.2018.00548 10.1006/taap.2001.9328 10.1034/j.1399-0004.2001.600402.x 10.3390/metabo11060368 10.1016/j.etap.2007.10.017 10.1016/j.envint.2018.11.050 10.1161/01.hyp.36.2.226 10.1523/JNEUROSCI.4925-04.2005 10.1093/hmg/dds046 10.2337/diabetes.50.11.2540 10.1016/j.biopha.2020.110785 10.1079/bjn20061787 10.1159/000328122 10.3389/fphys.2019.00094 10.1007/s00204-018-2177-0 10.1089/met.2008.0070 10.1038/oby.2007.351 10.1016/j.scitotenv.2018.07.087 10.1111/nyas.13263 10.1096/fasebj.29.1_supplement.650.1 10.1038/s41598-017-16820-5 10.1089/met.2008.0026 10.1016/j.envpol.2021.117855 10.1093/toxsci/kfy129 10.1289/ehp.01109399 10.1038/srep27854 10.1016/j.nut.2017.10.018 10.1038/s41598-017-17204-5 10.1093/nar/29.9.e45 10.3389/fendo.2018.00648 10.14341/2071-8713-5281 10.1146/annurev-physiol-012110-142200 10.1016/j.taap.2011.07.014 10.1124/dmd.119.086538 10.1016/j.ecoenv.2021.112530 10.1152/ajpendo.00451.2006 10.1016/j.taap.2005.05.010 10.1111/j.1439-0396.2007.00752.x 10.1038/s41598-020-74853-9 10.3390/molecules22071218 10.1289/ehp.8554 10.1677/JME-08-0132 10.1161/circ.122.suppl_21.A18103 10.2337/dc08-0850 10.1016/j.envres.2014.04.009 10.1021/acs.est.7b00565 10.3350/cmh.2018.0011 10.1007/s12035-019-01864-7 10.1016/j.celrep.2014.08.057 10.1038/nprot.2013.055 10.1093/toxsci/kfi288 10.1038/s41598-020-74617-5 10.1210/endocr/bqaa168 10.1016/j.envres.2015.03.037 10.3109/10408444.2015.1089471 10.1007/s00125-015-3496-9 10.1038/nri2653 10.1186/s40608-014-0031-3 10.1007/s00204-021-03163-4 10.1177/0192623311429973 10.1002/jat.4056 10.1002/jbt.22485 10.3389/fendo.2020.00379 10.3389/fnins.2021.695367 10.15252/embr.201949828 10.1021/es405524b 10.1289/ehp.1104802 10.1016/j.envpol.2020.115634 10.1371/journal.pone.0184006 10.12965/jer.140100 10.1242/dmm.026609 10.1053/jhep.2003.50161 10.1371/journal.pone.0094583 10.1016/j.molmet.2017.04.011 10.1006/taap.1996.0164 10.1038/emm.2015.122 10.1016/j.envres.2010.01.004 10.1038/nm1775 10.1186/1475-2840-10-36 10.1016/j.chemosphere.2018.06.108 |
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| Copyright | Copyright © 2022 Kozlova, Denys, Benedum, Valdez, Enriquez, Bishay, Chinthirla, Truong, Krum, DiPatrizio, Deol, Martins-Green and Curras-Collazo. Copyright © 2022 Kozlova, Denys, Benedum, Valdez, Enriquez, Bishay, Chinthirla, Truong, Krum, DiPatrizio, Deol, Martins-Green and Curras-Collazo 2022 Kozlova, Denys, Benedum, Valdez, Enriquez, Bishay, Chinthirla, Truong, Krum, DiPatrizio, Deol, Martins-Green and Curras-Collazo |
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| Keywords | leptin - adiponectin polybrominated diphenyl ethers (PBDEs) dyslipidemia (DLP) endocrine-disrupting chemical (EDC) fatty liver metabolic syndrome & type II diabetes hypothalamus maternal |
| Language | English |
| License | Copyright © 2022 Kozlova, Denys, Benedum, Valdez, Enriquez, Bishay, Chinthirla, Truong, Krum, DiPatrizio, Deol, Martins-Green and Curras-Collazo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ORCID ID: Elena V. Kozlova, orcid.org/0000-0002-4691-6618; Maximilian E. Denys, orcid.org/0000-0002-7423-6265; Matthew C. Valdez, orcid.org/0000-0002-8227-7921; Anthony E. Bishay, orcid.org/0000-0002-6057-3770; Poonamjot Deol, orcid.org/0000-0002-7109-0619; Margarita C. Curras-Collazo, orcid.org/0000-0002-0189-4179 Reviewed by: Tomohiko Isobe, National Institute for Environmental Studies (NIES), Japan; Taisen Iguchi, Graduate University for Advanced Studies (Sokendai), Japan This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology Edited by: Edith Sánchez-Jaramillo, National Institute of Psychiatry Ramon de la Fuente Muñiz (INPRFM), Mexico |
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| References | Wen (B20) 2019; 670 Alcalá (B105) 2019; 10 Helaleh (B13) 2018; 209 Cotter (B50) 2020; 158 Kozlova (B16) 2020; 10 Ramírez-Zacarías (B40) 1992; 97 Sharma (B83) 2002; 178 Tinsley (B38) 2004; 12 Lee (B48) 2014; 10 Mellor (B88) 2016; 46 Alberti (B1) 2010; 7 Lim (B17) 2008; 31 Li (B79) 2007; 293 Loria (B64) 2013; 43 Tsuru (B95) 2020; 10 Grün (B100) 2007; 8 Zhang (B11) 2016; 6 D’souza (B68) 2017; 6 Nguyen (B44) 2020; 57 B37 Turyk (B70) 2015; 140 Casals-Casas (B99) 2011; 73 Han (B98) 2016; 48 Wang (B24) 2018; 92 Sponton (B104) 2020; 21 Fan (B77) 1997; 385 Toniazzo (B85) 2018; 50 Guha (B108) 2021; 278 Shah (B57) 2011; 256 Contreras (B29) 2014; 9 Dunnick (B15) 2012; 40 Burdakov (B28) 2005; 25 Nguyen (B92) 2008; 92 Turner (B53) 2009; 9 Suvorov (B61) 2020; 12 Dunnick (B52) 2018; 92 Vuong (B103) 2019; 123 Rotundo (B67) 2018; 24 Khalil (B10) 2018; 9 B56 Pfaffl (B43) 2001; 29 Yang (B21) 2018; 644 Ruigrok (B27) 2021; 15 Zhao (B42) 2017; 22 Michaud (B81) 2001; 60 Stapleton (B35) 2012; 120 (B32) 2011 Armstrong (B23) 2020; 34 Fan (B31) 2007; 1179 Tartu (B59) 2017; 7 McIntyre (B14) 2015; 2 Vail (B80) 2020; 161 Mehlem (B39) 2013; 8 Darrow (B8) 2017; 51 Kozlova (B34) 2022; 96 Buettner (B72) 2008; 14 Abbasi (B5) 2019; 53 Woods (B33) 2012; 21 Kodavanti (B97) 2002; 68 Meerts (B101) 2001; 109 Timper (B25) 2017; 10 Walley (B73) 2021; 41 Luthe (B94) 2008; 25 Albarado (B78) 2004; 145 Kamstra (B19) 2014; 48 Hoppe (B60) 2007; 15 Swedenborg (B91) 2009; 43 Erkin-Cakmak (B18) 2015; 123 Windham (B66) 2010; 110 Taveau (B86) 2015; 58 Gump (B106) 2014; 132 Bankhead (B41) 2017; 7 Sanyal (B58) 2015; 19 Stoker (B102) 2005; 207 Hayashi (B109) 2020; 11 Morse (B84) 1996; 139 Negi (B93) 2021; 289 Moler (B3) Koh (B71) 2008; 117 Vandenberg (B54) 2012; 33 Scoville (B12) 2019; 47 Zheng (B45) 2015; 30 Sanders (B90) 2005; 88 Gutierrez (B87) 2015; 29 Tung (B22) 2014; 9 Marraudino (B74) 2021; 11 Vinken (B89) 2015; 28 Jeppesen (B49) 2000; 36 Lonardo (B62) 2019; 70 Marchesini (B51) 2003; 37 Diéguez (B30) 2011; 94 Turcotte (B96) 2015; 97 Fischer (B36) 2006; 114 Grundy (B46) 2008; 6 Leijs (B65) 2017; 12 Wahlang (B63) 2013; 41 Cai (B6) 2020; 267 Li (B47) 2011; 10 Gao (B107) 2021; 222 Hurley (B7) 2017; 51 Boudreau (B2) 2009; 7 Wren (B76) 2001; 50 Bruell (B55) 1962; 135 Caron (B26) 2017; 1391 Snow (B82) 2018; 164 Lyche (B9) 2015; 74 Shabalala (B69) 2020; 131 Tudurí (B4) 2018; 9 Gil-Campos (B75) 2006; 96 |
| References_xml | – volume: 74 year: 2015 ident: B9 article-title: Human health risk associated with brominated flame-retardants (BFRs) publication-title: Environ Int doi: 10.1016/j.envint.2014.09.006 contributor: fullname: Lyche – volume: 53 year: 2019 ident: B5 article-title: Global Historical Stocks and Emissions of PBDEs publication-title: Environ Sci Technol doi: 10.1021/acs.est.8b07032 contributor: fullname: Abbasi – volume: 70 year: 2019 ident: B62 article-title: Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps publication-title: Hepatology doi: 10.1002/hep.30626 contributor: fullname: Lonardo – volume: 43 start-page: 51 year: 2013 ident: B64 article-title: Liver and diabetes publication-title: A vicious circle. Hepatol Res doi: 10.1111/j.1872-034X.2012.01031.x contributor: fullname: Loria – volume: 158 year: 2020 ident: B50 article-title: Nonalcoholic Fatty Liver Disease 2020: The State of the Disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2020.01.052 contributor: fullname: Cotter – volume: 123 year: 2015 ident: B18 article-title: In utero and childhood polybrominated diphenyl ether exposures and body mass at age 7 years: the CHAMACOS study publication-title: Environ Health Perspect doi: 10.1289/ehp.1408417 contributor: fullname: Erkin-Cakmak – volume: 12 year: 2004 ident: B38 article-title: Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis publication-title: Obes Res doi: 10.1038/oby.2004.20 contributor: fullname: Tinsley – volume: 145 year: 2004 ident: B78 article-title: Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice publication-title: Endocrinology doi: 10.1210/en.2003-0452 contributor: fullname: Albarado – volume: 1179 year: 2007 ident: B31 article-title: Thermogenesis activated by central melanocortin signaling is dependent on neurons in the rostral raphe pallidus (rRPa) area publication-title: Brain Res doi: 10.1016/j.brainres.2007.04.006 contributor: fullname: Fan – volume: 135 year: 1962 ident: B55 article-title: Strain and sex differences in serum cholesterol levels of mice publication-title: Science doi: 10.1126/science.135.3508.1071 contributor: fullname: Bruell – volume: 51 year: 2017 ident: B8 article-title: Predictors of Serum Polybrominated Diphenyl Ether (PBDE) Concentrations among Children Aged 1–5 Years publication-title: Environ Sci Technol doi: 10.1021/acs.est.6b04696 contributor: fullname: Darrow – volume: 12 year: 2020 ident: B61 article-title: Rat liver epigenome programing by perinatal exposure to 2,2’,4’4’-tetrabromodiphenyl ether publication-title: Epigenomics doi: 10.2217/epi-2019-0315 contributor: fullname: Suvorov – volume: 8 year: 2007 ident: B100 article-title: Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis publication-title: Rev Endocr Metab Disord doi: 10.1007/s11154-007-9049-x contributor: fullname: Grün – volume: 41 year: 2013 ident: B63 article-title: Toxicant-associated steatohepatitis publication-title: Toxicol Pathol doi: 10.1177/0192623312468517 contributor: fullname: Wahlang – volume: 28 year: 2015 ident: B89 article-title: Adverse Outcome Pathways and Drug-Induced Liver Injury Testing publication-title: Chem Res Toxicol doi: 10.1021/acs.chemrestox.5b00208 contributor: fullname: Vinken – volume: 19 start-page: 597 year: 2015 ident: B58 article-title: Profile of liver enzymes in non-alcoholic fatty liver disease in patients with impaired glucose tolerance and newly detected untreated type 2 diabetes publication-title: Indian J Endocrinol Metab doi: 10.4103/2230-8210.163172 contributor: fullname: Sanyal – volume: 33 start-page: 378 year: 2012 ident: B54 article-title: Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses publication-title: Endocr Rev doi: 10.1210/er.2011-1050 contributor: fullname: Vandenberg – volume: 670 start-page: 67 year: 2019 ident: B20 article-title: The brominated flame retardant PBDE 99 promotes adipogenesis via regulating mitotic clonal expansion and PPARγ expression publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2019.03.201 contributor: fullname: Wen – volume: 385 year: 1997 ident: B77 article-title: Role of melanocortinergic neurons in feeding and the agouti obesity syndrome publication-title: Nature doi: 10.1038/385165a0 contributor: fullname: Fan – volume: 97 year: 1992 ident: B40 article-title: Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O publication-title: Histochemistry doi: 10.1007/BF00316069 contributor: fullname: Ramírez-Zacarías – volume: 117 year: 2008 ident: B71 article-title: Leptin and cardiovascular disease: response to therapeutic interventions publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.107.741645 contributor: fullname: Koh – volume: 278 year: 2021 ident: B108 article-title: Effects of two potential probiotic Lactobacillus bacteria on adipogenesis publication-title: vitro. Life Sci doi: 10.1016/j.lfs.2021.119538 contributor: fullname: Guha – volume: 97 year: 2015 ident: B96 article-title: Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites publication-title: J Leukoc Biol doi: 10.1189/jlb.3RU0115-021R contributor: fullname: Turcotte – volume: 30 year: 2015 ident: B45 article-title: Maternal and post-weaning high-fat, high-sucrose diet modulates glucose homeostasis and hypothalamic POMC promoter methylation in mouse offspring publication-title: Metab Brain Dis doi: 10.1007/s11011-015-9678-9 contributor: fullname: Zheng – volume: 92 year: 2018 ident: B52 article-title: PBDE-47 and PBDE mixture (DE-71) toxicities and liver transcriptomic changes at PND 22 after in utero/postnatal exposure in the rat publication-title: Arch Toxicol doi: 10.1007/s00204-018-2292-y contributor: fullname: Dunnick – volume: 68 year: 2002 ident: B97 article-title: Differential effects of polybrominated diphenyl ethers and polychlorinated biphenyls on [3H]arachidonic acid release in rat cerebellar granule neurons publication-title: Toxicol Sci doi: 10.1093/toxsci/68.2.451 contributor: fullname: Kodavanti – volume: 9 year: 2018 ident: B10 article-title: Developmental Exposure to 2,2′,4,4′-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice publication-title: Front Endocrinol doi: 10.3389/fendo.2018.00548 contributor: fullname: Khalil – volume: 178 year: 2002 ident: B83 article-title: In vitro effects of polychlorinated biphenyls and hydroxy metabolites on nitric oxide synthases in rat brain publication-title: Toxicol Appl Pharmacol doi: 10.1006/taap.2001.9328 contributor: fullname: Sharma – volume: 60 year: 2001 ident: B81 article-title: The developmental program of the hypothalamus and its disorders publication-title: Clin Genet doi: 10.1034/j.1399-0004.2001.600402.x contributor: fullname: Michaud – volume: 11 year: 2021 ident: B74 article-title: Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors publication-title: Metabolites doi: 10.3390/metabo11060368 contributor: fullname: Marraudino – volume: 25 year: 2008 ident: B94 article-title: Receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls: A theoretical structure–activity assessment publication-title: Environ Toxicol Pharmacol doi: 10.1016/j.etap.2007.10.017 contributor: fullname: Luthe – volume: 123 year: 2019 ident: B103 article-title: Exposure to polybrominated diphenyl ethers (PBDEs) during childhood and adiposity measures at age 8 years publication-title: Environ Int doi: 10.1016/j.envint.2018.11.050 contributor: fullname: Vuong – volume: 36 year: 2000 ident: B49 article-title: High triglycerides and low HDL cholesterol and blood pressure and risk of ischemic heart disease publication-title: Hypertension doi: 10.1161/01.hyp.36.2.226 contributor: fullname: Jeppesen – volume: 25 year: 2005 ident: B28 article-title: Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4925-04.2005 contributor: fullname: Burdakov – volume: 21 year: 2012 ident: B33 article-title: Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation publication-title: Hum Mol Genet doi: 10.1093/hmg/dds046 contributor: fullname: Woods – volume: 50 year: 2001 ident: B76 article-title: Ghrelin causes hyperphagia and obesity in rats publication-title: Diabetes doi: 10.2337/diabetes.50.11.2540 contributor: fullname: Wren – volume: 131 year: 2020 ident: B69 article-title: The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling publication-title: BioMed Pharmacother doi: 10.1016/j.biopha.2020.110785 contributor: fullname: Shabalala – volume: 96 year: 2006 ident: B75 article-title: Ghrelin: a hormone regulating food intake and energy homeostasis publication-title: Br J Nutr doi: 10.1079/bjn20061787 contributor: fullname: Gil-Campos – volume: 94 start-page: 1 year: 2011 ident: B30 article-title: Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins publication-title: Neuroendocrinology doi: 10.1159/000328122 contributor: fullname: Diéguez – ident: B37 – volume-title: Guide for the Care and Use of Laboratory Animals year: 2011 ident: B32 – volume: 10 year: 2019 ident: B105 article-title: Mechanisms of Impaired Brown Adipose Tissue Recruitment in Obesity publication-title: Front Physiol doi: 10.3389/fphys.2019.00094 contributor: fullname: Alcalá – volume: 92 year: 2018 ident: B24 article-title: In utero and lactational exposure to BDE-47 promotes obesity development in mouse offspring fed a high-fat diet: impaired lipid metabolism and intestinal dysbiosis publication-title: Arch Toxicol doi: 10.1007/s00204-018-2177-0 contributor: fullname: Wang – volume: 7 year: 2009 ident: B2 article-title: Health care utilization and costs by metabolic syndrome risk factors publication-title: Metab Syndr Relat Disord doi: 10.1089/met.2008.0070 contributor: fullname: Boudreau – volume: 15 year: 2007 ident: B60 article-title: Polybrominated diphenyl ethers as endocrine disruptors of adipocyte metabolism publication-title: Obesity doi: 10.1038/oby.2007.351 contributor: fullname: Hoppe – volume: 644 year: 2018 ident: B21 article-title: The brominated flame retardant BDE 47 upregulates purine metabolism and mitochondrial respiration to promote adipocyte differentiation publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2018.07.087 contributor: fullname: Yang – volume: 1391 start-page: 35 year: 2017 ident: B26 article-title: Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis publication-title: Ann N Y Acad Sci doi: 10.1111/nyas.13263 contributor: fullname: Caron – volume: 29 year: 2015 ident: B87 article-title: Developmental Exposure to Indoor Flame Retardants Disrupts Sympathetic and Hypothalamic-Pituitary-Adrenal (HPA) Axis Activity in Osmotic Challenged Rats publication-title: FASEB J doi: 10.1096/fasebj.29.1_supplement.650.1 contributor: fullname: Gutierrez – volume: 7 start-page: 16487 year: 2017 ident: B59 article-title: Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears publication-title: Sci Rep doi: 10.1038/s41598-017-16820-5 contributor: fullname: Tartu – volume: 6 year: 2008 ident: B46 article-title: Variable contributions of fat content and distribution to metabolic syndrome risk factors publication-title: Metab Syndr Relat Disord doi: 10.1089/met.2008.0026 contributor: fullname: Grundy – volume: 289 year: 2021 ident: B93 article-title: An adverse outcome pathway based in vitro characterization of novel flame retardants-induced hepatic steatosis publication-title: Environ pollut doi: 10.1016/j.envpol.2021.117855 contributor: fullname: Negi – volume: 164 start-page: 9 year: 2018 ident: B82 article-title: Neuroendocrine Regulation of Air Pollution Health Effects: Emerging Insights publication-title: Toxicol Sci doi: 10.1093/toxsci/kfy129 contributor: fullname: Snow – volume: 109 start-page: 399 year: 2001 ident: B101 article-title: In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds publication-title: Environ Health Perspect doi: 10.1289/ehp.01109399 contributor: fullname: Meerts – volume: 6 year: 2016 ident: B11 article-title: Environmental exposure to BDE47 is associated with increased diabetes prevalence: Evidence from community-based case-control studies and an animal experiment publication-title: Sci Rep doi: 10.1038/srep27854 contributor: fullname: Zhang – volume: 50 start-page: 18 year: 2018 ident: B85 article-title: Sex-specific effects of prepubertal stress and high-fat diet on leptin signaling in rats publication-title: Nutrition doi: 10.1016/j.nut.2017.10.018 contributor: fullname: Toniazzo – volume: 7 start-page: 16878 year: 2017 ident: B41 article-title: QuPath: Open source software for digital pathology image analysis publication-title: Sci Rep doi: 10.1038/s41598-017-17204-5 contributor: fullname: Bankhead – volume: 29 year: 2001 ident: B43 article-title: A new mathematical model for relative quantification in real-time RT–PCR publication-title: Nucleic Acids Res doi: 10.1093/nar/29.9.e45 contributor: fullname: Pfaffl – volume: 9 year: 2018 ident: B4 article-title: Timing of Exposure and Bisphenol-A: Implications for Diabetes Development publication-title: Front Endocrinol doi: 10.3389/fendo.2018.00648 contributor: fullname: Tudurí – volume: 7 year: 2010 ident: B1 article-title: Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World HeartFederation; International Atherosclerosis Society; and International Association for the Study of Obesity publication-title: Obes Metab doi: 10.14341/2071-8713-5281 contributor: fullname: Alberti – volume: 73 year: 2011 ident: B99 article-title: Endocrine Disruptors: From Endocrine to Metabolic Disruption publication-title: Annu Rev Physiol doi: 10.1146/annurev-physiol-012110-142200 contributor: fullname: Casals-Casas – volume: 256 year: 2011 ident: B57 article-title: Altered cardiovascular reactivity and osmoregulation during hyperosmotic stress in adult rats developmentally exposed to polybrominated diphenyl ethers (PBDEs) publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2011.07.014 contributor: fullname: Shah – volume: 47 year: 2019 ident: B12 article-title: Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome–Related Aqueous Metabolites in Mice publication-title: Drug Metab Dispos doi: 10.1124/dmd.119.086538 contributor: fullname: Scoville – volume: 222 year: 2021 ident: B107 article-title: Impacts of PBDE-47 exposure before, during and after pregnancy on the maternal gut microbiome and its association with host metabolism publication-title: Ecotoxicol Environ Saf doi: 10.1016/j.ecoenv.2021.112530 contributor: fullname: Gao – volume: 293 year: 2007 ident: B79 article-title: Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00451.2006 contributor: fullname: Li – volume: 207 start-page: 78 year: 2005 ident: B102 article-title: In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2005.05.010 contributor: fullname: Stoker – volume: 92 year: 2008 ident: B92 article-title: Liver lipid metabolism publication-title: J Anim Physiol Anim Nutr doi: 10.1111/j.1439-0396.2007.00752.x contributor: fullname: Nguyen – volume: 10 start-page: 1 year: 2020 ident: B16 article-title: Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring publication-title: Sci Rep doi: 10.1038/s41598-020-74853-9 contributor: fullname: Kozlova – volume: 22 year: 2017 ident: B42 article-title: Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice publication-title: Molecules doi: 10.3390/molecules22071218 contributor: fullname: Zhao – volume: 114 year: 2006 ident: B36 article-title: Children show highest levels of polybrominated diphenyl ethers in a California family of four: a case study publication-title: Environ Health Perspect doi: 10.1289/ehp.8554 contributor: fullname: Fischer – volume: 43 start-page: 1 year: 2009 ident: B91 article-title: Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders publication-title: J Mol Endocrinol doi: 10.1677/JME-08-0132 contributor: fullname: Swedenborg – ident: B3 article-title: Abstract 18103: Medical Costs Associated with All Combinations of Metabolic Syndrome Components publication-title: Circulation doi: 10.1161/circ.122.suppl_21.A18103 contributor: fullname: Moler – volume: 31 year: 2008 ident: B17 article-title: Association of Brominated Flame Retardants With Diabetes and Metabolic Syndrome in the U.S. Population, 2003–2004 publication-title: Diabetes Care doi: 10.2337/dc08-0850 contributor: fullname: Lim – volume: 132 year: 2014 ident: B106 article-title: Polybrominated diphenyl ether (PBDE) exposure in children: possible associations with cardiovascular and psychological functions publication-title: Environ Res doi: 10.1016/j.envres.2014.04.009 contributor: fullname: Gump – volume: 51 year: 2017 ident: B7 article-title: Temporal Evaluation of Polybrominated Diphenyl Ether (PBDE) Serum Levels in Middle-Aged and Older California Women, 2011-2015 publication-title: Environ Sci Technol doi: 10.1021/acs.est.7b00565 contributor: fullname: Hurley – volume: 24 start-page: 392 year: 2018 ident: B67 article-title: The Association of leptin with severity of non-alcoholic fatty liver disease: A population-based study publication-title: Clin Mol Hepatol doi: 10.3350/cmh.2018.0011 contributor: fullname: Rotundo – volume: 57 year: 2020 ident: B44 article-title: Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice publication-title: Mol Neurobiol doi: 10.1007/s12035-019-01864-7 contributor: fullname: Nguyen – volume: 9 year: 2014 ident: B29 article-title: Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance publication-title: Cell Rep doi: 10.1016/j.celrep.2014.08.057 contributor: fullname: Contreras – volume: 8 year: 2013 ident: B39 article-title: Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease publication-title: Nat Protoc doi: 10.1038/nprot.2013.055 contributor: fullname: Mehlem – volume: 88 year: 2005 ident: B90 article-title: Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components publication-title: Toxicol Sci doi: 10.1093/toxsci/kfi288 contributor: fullname: Sanders – volume: 10 start-page: 17593 year: 2020 ident: B95 article-title: HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse publication-title: Sci Rep doi: 10.1038/s41598-020-74617-5 contributor: fullname: Tsuru – volume: 161 year: 2020 ident: B80 article-title: Organophosphate Flame Retardants Excite Arcuate Melanocortin Circuitry and Increase Neuronal Sensitivity to Ghrelin in Adult Mice publication-title: Endocrinology doi: 10.1210/endocr/bqaa168 contributor: fullname: Vail – volume: 140 year: 2015 ident: B70 article-title: Persistent organic pollutants and biomarkers of diabetes risk in a cohort of Great Lakes sport caught fish consumers publication-title: Environ Res doi: 10.1016/j.envres.2015.03.037 contributor: fullname: Turyk – volume: 46 year: 2016 ident: B88 article-title: The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways publication-title: Crit Rev Toxicol doi: 10.3109/10408444.2015.1089471 contributor: fullname: Mellor – volume: 58 year: 2015 ident: B86 article-title: Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats publication-title: Diabetologia doi: 10.1007/s00125-015-3496-9 contributor: fullname: Taveau – volume: 9 start-page: 799 year: 2009 ident: B53 article-title: Intestinal mucosal barrier function in health and disease publication-title: Nat Rev Immunol doi: 10.1038/nri2653 contributor: fullname: Turner – volume: 2 year: 2015 ident: B14 article-title: Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency publication-title: BMC Obes doi: 10.1186/s40608-014-0031-3 contributor: fullname: McIntyre – volume: 96 year: 2022 ident: B34 article-title: Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71 publication-title: Arch Toxicol doi: 10.1007/s00204-021-03163-4 contributor: fullname: Kozlova – volume: 40 start-page: 93 year: 2012 ident: B15 article-title: Characterization of polybrominated diphenyl ether toxicity in Wistar Han rats and use of liver microarray data for predicting disease susceptibilities publication-title: Toxicol Pathol doi: 10.1177/0192623311429973 contributor: fullname: Dunnick – volume: 41 year: 2021 ident: B73 article-title: Maternal organophosphate flame-retardant exposure alters offspring feeding, locomotor and exploratory behaviors in a sexually-dimorphic manner in mice publication-title: J Appl Toxicol doi: 10.1002/jat.4056 contributor: fullname: Walley – volume: 34 start-page: e22485 year: 2020 ident: B23 article-title: 2,2’,4,4’,5-Pentabromodiphenyl ether induces lipid accumulation throughout differentiation in 3T3-L1 and human preadipocytes publication-title: vitro. J Biochem Mol Toxicol doi: 10.1002/jbt.22485 contributor: fullname: Armstrong – volume: 11 year: 2020 ident: B109 article-title: Oxytocin Ameliorates Impaired Behaviors of High Fat Diet-Induced Obese Mice publication-title: Front Endocrinol doi: 10.3389/fendo.2020.00379 contributor: fullname: Hayashi – volume: 15 year: 2021 ident: B27 article-title: Modulation of the Hypothalamic Nutrient Sensing Pathways by Sex and Early-Life Stress publication-title: Front Neurosci doi: 10.3389/fnins.2021.695367 contributor: fullname: Ruigrok – ident: B56 – volume: 21 year: 2020 ident: B104 article-title: The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication publication-title: EMBO Rep doi: 10.15252/embr.201949828 contributor: fullname: Sponton – volume: 48 year: 2014 ident: B19 article-title: Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47 publication-title: Environ Sci Technol doi: 10.1021/es405524b contributor: fullname: Kamstra – volume: 120 year: 2012 ident: B35 article-title: Serum PBDEs in a North Carolina toddler cohort: associations with hand wipes, house dust, and socioeconomic variables publication-title: Environ Health Perspect doi: 10.1289/ehp.1104802 contributor: fullname: Stapleton – volume: 267 year: 2020 ident: B6 article-title: Human exposure to PBDEs in e-waste areas: A review publication-title: Environ pollut doi: 10.1016/j.envpol.2020.115634 contributor: fullname: Cai – volume: 12 year: 2017 ident: B65 article-title: Alterations in the programming of energy metabolism in adolescents with background exposure to dioxins, dl-PCBs and PBDEs publication-title: PloS One doi: 10.1371/journal.pone.0184006 contributor: fullname: Leijs – volume: 10 year: 2014 ident: B48 article-title: Role of adiponectin in metabolic and cardiovascular disease publication-title: J Exerc Rehabil doi: 10.12965/jer.140100 contributor: fullname: Lee – volume: 10 year: 2017 ident: B25 article-title: Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity publication-title: Dis Model Mech doi: 10.1242/dmm.026609 contributor: fullname: Timper – volume: 37 year: 2003 ident: B51 article-title: Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome publication-title: Hepatology doi: 10.1053/jhep.2003.50161 contributor: fullname: Marchesini – volume: 9 year: 2014 ident: B22 article-title: Induction of adipocyte differentiation by polybrominated diphenyl ethers (PBDEs) in 3T3-L1 cells publication-title: PloS One doi: 10.1371/journal.pone.0094583 contributor: fullname: Tung – volume: 6 year: 2017 ident: B68 article-title: The glucoregulatory actions of leptin publication-title: Mol Metab doi: 10.1016/j.molmet.2017.04.011 contributor: fullname: D’souza – volume: 139 year: 1996 ident: B84 article-title: Persistent alterations in regional brain glial fibrillary acidic protein and synaptophysin levels following pre- and postnatal polychlorinated biphenyl exposure publication-title: Toxicology and applied pharmacology doi: 10.1006/taap.1996.0164 contributor: fullname: Morse – volume: 48 year: 2016 ident: B98 article-title: Regulation of glucose metabolism from a liver-centric perspective publication-title: Exp Mol Med doi: 10.1038/emm.2015.122 contributor: fullname: Han – volume: 110 year: 2010 ident: B66 article-title: Body burdens of brominated flame retardants and other persistent organo-halogenated compounds and their descriptors in US girls publication-title: Environ Res doi: 10.1016/j.envres.2010.01.004 contributor: fullname: Windham – volume: 14 year: 2008 ident: B72 article-title: Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms publication-title: Nat Med doi: 10.1038/nm1775 contributor: fullname: Buettner – volume: 10 year: 2011 ident: B47 article-title: Serum leptin is associated with cardiometabolic risk and predicts metabolic syndrome in Taiwanese adults publication-title: Cardiovasc Diabetol doi: 10.1186/1475-2840-10-36 contributor: fullname: Li – volume: 209 year: 2018 ident: B13 article-title: Association of polybrominated diphenyl ethers in two fat compartments with increased risk of insulin resistance in obese individuals publication-title: Chemosphere doi: 10.1016/j.chemosphere.2018.06.108 contributor: fullname: Helaleh |
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| SubjectTerms | Adiponectin Agouti-Related Protein Animals Cholesterol Corn Oil Endocrine Disruptors - toxicity endocrine-disrupting chemical (EDC) Endocrinology Environmental Pollutants - toxicity fatty liver Female Flame Retardants - toxicity Halogenated Diphenyl Ethers - toxicity Homeostasis Leptin leptin - adiponectin Male maternal metabolic syndrome & type II diabetes Mice Mice, Inbred C57BL Organophosphates Persistent Organic Pollutants polybrominated diphenyl ethers (PBDEs) Polychlorinated Biphenyls Pregnancy Sex Factors Triglycerides |
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| Title | Developmental exposure to indoor flame retardants and hypothalamic molecular signatures: Sex-dependent reprogramming of lipid homeostasis |
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