SRSF1 Deficiency Impairs the Late Thymocyte Maturation and the CD8 Single-Positive Lineage Fate Decision

• Published in: Frontiers in immunology Vol. 13; p. 838719
• Main Authors: Ji, Ce, Bao, Li, Yuan, Shunzong, Qi, Zhihong, Wang, Fang, You, Menghao, Yu, Guotao, Liu, Jingjing, Cui, Xiao, Wang, Zhao, Liu, Juanjuan, Guo, Wenhui, Feng, Mingxia, Chen, Feng, Kang, Youmin, Yu, Shuyang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.01.2022
• Subjects: Animals; CD4 Antigens - genetics; CD4 Antigens - metabolism; CD8+ T cell; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell Differentiation - genetics; Cell Differentiation - immunology; Cell Lineage - genetics; Core Binding Factor Alpha 3 Subunit - genetics; Core Binding Factor Alpha 3 Subunit - metabolism; development; Down-Regulation; Gene Expression Regulation - immunology; Hematopoiesis; Immunology; lineage choice; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Runx3; Serine-Arginine Splicing Factors - deficiency; Serine-Arginine Splicing Factors - genetics; SRSF1; thymocyte; Thymocytes - metabolism; lineage choice; development; Runx3; CD8+ T cell; SRSF1; thymocyte

The underlying mechanisms of thymocyte development and lineage determination remain incompletely understood, and the emerging evidences demonstrated that RNA binding proteins (RBPs) are deeply involved in governing T cell fate in thymus. Serine/arginine-rich splicing factor 1 (SRSF1), as a classical...