Glioblastoma Immunotherapy Targeting the Innate Immune Checkpoint CD47-SIRPα Axis

• Published in: Frontiers in immunology Vol. 11; p. 593219
• Main Authors: Hu, Jinyang, Xiao, Qungen, Dong, Minhai, Guo, Dongsheng, Wu, Xudong, Wang, Baofeng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.11.2020
• Subjects: CD47-SIRPα; glioblastoma; glioblastoma microenvironment; immune checkpoint; Immunology; tumor-associated macrophages/microglia; glioblastoma microenvironment; glioblastoma; CD47-SIRPα; tumor-associated macrophages/microglia; immune checkpoint

Glioblastoma Multiforme (GBM) is the most common and aggressive form of intracranial tumors with poor prognosis. In recent years, tumor immunotherapy has been an attractive strategy for a variety of tumors. Currently, most immunotherapies take advantage of the adaptive anti-tumor immunity, such as c...