Influence of High Intensity Focused Ultrasound on the Microstructure and c-di-GMP Signaling of Pseudomonas aeruginosa Biofilms

• Published in: Frontiers in microbiology Vol. 11; p. 599407
• Main Authors: Bharatula, Lakshmi Deepika, Marsili, Enrico, Rice, Scott A., Kwan, James J.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.12.2020
• Subjects: biofilm; cyclic-di-GMP; HIFU; Microbiology; microstructural effect; Pseudomonas aeruginosa; HIFU; Pseudomonas aeruginosa; cyclic-di-GMP; microstructural effect; biofilm

Bacterial biofilms are typically more tolerant to antimicrobials compared to bacteria in the planktonic phase and therefore require alternative treatment approaches. Mechanical biofilm disruption from ultrasound may be such an alternative by circumventing rapid biofilm adaptation to antimicrobial ag...