Induction of Krüppel-Like Factor 4 Mediates Polymorphonuclear Neutrophil Activation in Streptococcus pneumoniae Infection

• Published in: Frontiers in microbiology Vol. 11; p. 582070
• Main Authors: Bhattacharyya, Aritra, Herta, Toni, Conrad, Claudia, Frey, Doris, García, Pedro, Suttorp, Norbert, Hippenstiel, Stefan, Zahlten, Janine
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 03.02.2021
• Subjects: infectious diseases; innate immunity; Krüppel-like factor 4; Microbiology; neutrophils; S. pneumoniae; S. pneumoniae; innate immunity; neutrophils; infectious diseases; Krüppel-like factor 4

The recruitment and activation of polymorphonuclear neutrophils (PMNs) are of central importance for the elimination of pathogens in bacterial infections. We investigated the Streptococcus pneumoniae -dependent induction of the transcription factor Krüppel-like factor (KLF) 4 in PMNs as a potential...