Involvement of the SIRT1/PGC-1α Signaling Pathway in Noise-Induced Hidden Hearing Loss

• Published in: Frontiers in physiology Vol. 13; p. 798395
• Main Authors: Liu, Yu-Hui, Jiang, Yi-Hong, Li, Cong-Cong, Chen, Xue-Min, Huang, Li-Gui, Zhang, Min, Ruan, Bai, Wang, Xiao-Cheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.05.2022
• Subjects: cochlea; noise-induced hidden hearing loss; oxidative stress; Physiology; ribbon synapse; Sirtuin 1; ribbon synapse; cochlea; noise-induced hidden hearing loss; Sirtuin 1; oxidative stress

Objective: To establish an animal model of noise-induced hidden hearing loss (NIHHL), evaluate the dynamic changes in cochlear ribbon synapses and cochlear hair cell morphology, and observe the involvement of the SIRT1/PGC-1α signaling pathway in NIHHL. Methods: Male guinea pigs were randomly divide...