Regulation of γ-Aminobutyrate (GABA) Utilization in Corynebacterium glutamicum by the PucR-Type Transcriptional Regulator GabR and by Alternative Nitrogen and Carbon Sources

• Published in: Frontiers in microbiology Vol. 11; p. 544045
• Main Authors: Zhu, Lingfeng, Mack, Christina, Wirtz, Astrid, Kranz, Angela, Polen, Tino, Baumgart, Meike, Bott, Michael
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.10.2020
• Subjects: Actinobacteria; cAMP-dependent regulator GlxR; Corynebacterium glutamicum; Microbiology; nitrogen metabolism; PucR-type regulator GabR; γ-aminobutyrate; cAMP-dependent regulator GlxR; Corynebacterium glutamicum; nitrogen metabolism; γ-aminobutyrate; Actinobacteria; PucR-type regulator GabR; carbon metabolism

γ-Aminobutyric acid (GABA) is a non-proteinogenic amino acid mainly formed by decarboxylation of L-glutamate and is widespread in nature from microorganisms to plants and animals. In this study, we analyzed the regulation of GABA utilization by the Gram-positive soil bacterium , which serves as mode...