CCL24 contributes to HCC malignancy via RhoB- VEGFA-VEGFR2 angiogenesis pathway and indicates poor prognosis

• Published in: Oncotarget Vol. 8; no. 3; pp. 5135 - 5148
• Main Authors: Jin, Lei, Liu, Wei-Ren, Tian, Meng-Xin, Jiang, Xi-Fei, Wang, Han, Zhou, Pei-Yun, Ding, Zhen-Bin, Peng, Yuan-Fei, Dai, Zhi, Qiu, Shuang-Jian, Zhou, Jian, Fan, Jia, Shi, Ying-Hong
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 17.01.2017
• Subjects: Animals; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Chemokine CCL24 - genetics; Chemokine CCL24 - metabolism; Female; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Mice; Neoplasm Transplantation; Prognosis; Receptor, Fibroblast Growth Factor, Type 2 - metabolism; Receptors, CCR3 - metabolism; Research Paper; rhoB GTP-Binding Protein - metabolism; Survival Analysis; Th2 Cells - metabolism; Up-Regulation; Vascular Endothelial Growth Factor A - metabolism; CCL24; HCC; prognosis; RhoB; VEGFA

CCL24 is one chemotactic factor extensively studied in airway inflammation and colorectal cancer but less studied in hepatocellular carcinoma (HCC) retrospectively. So HCC tissue microarray (TMA) was used to estimate relationship between CCL24 and prognosis, cell experiments were conducted to study...