Transcriptome and Lipid Metabolomics-Based Discovery: Glycyrrhizic Acid Alleviates Tripterygium Glycoside Tablet-Induced Acute Liver Injury by Regulating the Activities of CYP and the Metabolism of Phosphoglycerides

• Published in: Frontiers in pharmacology Vol. 12; p. 822154
• Main Authors: Shi, Qiaoli, Wang, Qixin, Chen, Jiayun, Xia, Fei, Qiu, Chong, Li, Min, Zhao, Minghong, Zhang, Qian, Luo, Piao, Lu, Tianming, Zhang, Ying, Xu, Liting, He, Xueling, Zhong, Tianyu, Lin, Na, Guo, Qiuyan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.02.2022
• Subjects: glycyrrhizic acid; lipid metabolomics; liver injury; Pharmacology; transcriptome; tripterygium glycoside tablet; tripterygium glycoside tablet; liver injury; lipid metabolomics; glycyrrhizic acid; transcriptome

Background: Glycyrrhizic acid (GA) has been reported to be liver protective; however, the characters and underlying mechanisms of GA against tripterygium glycoside tablet (TGT)-induced acute liver injury remain unelucidated. Hypothesis/Purpose: We assumed that GA could relieve TGT-induced acute live...