Pneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages

• Published in: Frontiers in immunology Vol. 12; p. 573266
• Main Authors: Cole, Joby, Angyal, Adrienn, Emes, Richard D, Mitchell, Tim John, Dickman, Mark J, Dockrell, David H
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.05.2021
• Subjects: Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Cells, Cultured; Cytokines - genetics; Cytokines - metabolism; Epigenesis, Genetic; Gene Expression Profiling; histone post translational modifications; Histones - metabolism; Host-Pathogen Interactions; Humans; Immunology; Macrophages - metabolism; Macrophages - microbiology; Methylation; monocyte derived macrophages; pneumolysin; Protein Processing, Post-Translational; Proteome - metabolism; Proteomics - methods; Streptococcus pneumoniae; Streptococcus pneumoniae - genetics; Streptococcus pneumoniae - metabolism; Streptococcus pneumoniae - physiology; Streptolysins - genetics; Streptolysins - metabolism; tumour necrosis factor; monocyte derived macrophages; pneumolysin; tumour necrosis factor; histone post translational modifications; Streptococcus pneumoniae

Epigenetic modifications regulate gene expression in the host response to a diverse range of pathogens. The extent and consequences of epigenetic modification during macrophage responses to , and the role of pneumolysin, a key virulence factor, in influencing these responses, are currently unknown....