An Evaluation of the Mechanisms of Galacto-Oligosaccharide (GOS)-Induced IgE Cross-Linking on Basophils in GOS Allergy

• Published in: Frontiers in allergy Vol. 3; p. 840454
• Main Authors: Lee, Li Yuan Gabriella Nadine, Leow, Si Yuan, Wen, Hongmei, Soh, Jian Yi, Chiang, Wen Chin, Zhong, Youjia, Tham, Elizabeth Huiwen, Loh, Wenyin, Delsing, Dianne J., Lee, Bee Wah, Huang, Chiung-Hui
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.02.2022
• Subjects: Allergy; basophils; galacto-oligosaccharides; galacto-oligosaccharides allergy; galectin inhibitors; IgE cross-linking; basophils; galectin inhibitors; galacto-oligosaccharides allergy; IgE cross-linking; galacto-oligosaccharides

The prebiotics, galacto-oligosaccharides (GOS), are small carbohydrate molecules with 1–7 galactose units linked to glucose and have been shown to trigger IgE-mediated anaphylaxis in some cases following ingestion. It is still an unresolved question of how GOS cross-links IgE on basophils. In this s...