Analysis of chromatin data supports a role for CD14+ monocytes/macrophages in mediating genetic risk for juvenile idiopathic arthritis

• Published in: Frontiers in immunology Vol. 13; p. 913555
• Main Authors: Crinzi, Elizabeth A, Haley, Emma K, Poppenberg, Kerry E, Jiang, Kaiyu, Tutino, Vincent M, Jarvis, James N
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.09.2022
• Subjects: Arthritis, Juvenile - genetics; causal variant; Chromatin - genetics; genetics; Genome-Wide Association Study; haplotype; Humans; Immunology; juvenile arthritis; Lipopolysaccharide Receptors - immunology; macrophage; Macrophages; monocyte; Monocytes; causal variant; juvenile arthritis; genetics; haplotype; enhancers; macrophage; monocyte

Genome wide association studies (GWAS) have identified multiple regions that confer genetic risk for the polyarticular/oligoarticular forms of juvenile idiopathic arthritis (JIA). However, genome-wide scans do not identify the cells impacted by genetic polymorphisms on the risk haplotypes or the gen...