FXII (46C-->T) polymorphism and in vivo generation of FXII activity--gene frequencies and relationship in patients with coronary artery disease

• Published in: Thrombosis and haemostasis Vol. 81; no. 5; p. 745
• Main Authors: Kohler, H P, Futers, T S, Grant, P J
• Format: Journal Article
• Language: English
• Published: Germany 01.05.1999
• Subjects: Blood Coagulation; Coronary Disease - blood; Coronary Disease - genetics; Factor XII - genetics; Female; Humans; Male; Middle Aged; Mutation; Polymorphism, Genetic

Increased Factor XIIa concentrations have been found in association with coronary artery disease. Recently, a common 46 C to T point mutation in exon I of the factor XII gene has been described which is associated with lower FXII clotting activity and lower zymogen levels in relation to possession o...