Detection of Amyloid-β(1–42) Aggregation With a Nanostructured Electrochemical Sandwich Immunoassay Biosensor

• Published in: Frontiers in bioengineering and biotechnology Vol. 10; p. 853947
• Main Authors: Wang, Bing-Yu, Gu, Bien-Chen, Wang, Gou-Jen, Yang, Yuan-Han, Wu, Chia-Che
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.03.2022
• Subjects: aggregation; Alzheimer disease (AD); amyloid-β(1–42) peptide; Bioengineering and Biotechnology; electrochemical impedance spectroscopy(EIS); nanostructured biosensor; oligomers; nanostructured biosensor; Alzheimer disease (AD); aggregation; electrochemical impedance spectroscopy(EIS); amyloid-β(1–42) peptide; oligomers

Amyloid-β(1–42) [Aβ(1–42)] oligomer accumulations are associated with physiologic alterations in the brains of individuals with Alzheimer’s disease. In this study, we demonstrate that a nanostructured gold electrode with deposited gold nanoparticles, induced via electrochemical impedance spectroscop...