18α-Glycyrrhetinic Acid Induces Apoptosis of HL-60 Human Leukemia Cells through Caspases- and Mitochondria-Dependent Signaling Pathways

• Published in: Molecules (Basel, Switzerland) Vol. 21; no. 7; p. 872
• Main Authors: Huang, Yi-Chang, Kuo, Chao-Lin, Lu, Kung-Wen, Lin, Jen-Jyh, Yang, Jiun-Long, Wu, Rick Sai-Chuen, Wu, Ping-Ping, Chung, Jing-Gung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 01.07.2016; MDPI AG
• Subjects: 18α-glycyrrhetinic acid; Antineoplastic Agents - pharmacology; apoptosis; Apoptosis - drug effects; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; caspase-3; Caspases - metabolism; Cell Proliferation - drug effects; DNA Damage - drug effects; Gene Expression; Glycyrrhetinic Acid - analogs & derivatives; Glycyrrhetinic Acid - pharmacology; HL-60 Cells; Humans; Membrane Potential, Mitochondrial - drug effects; mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Protein Transport; Signal Transduction - drug effects; 18α-glycyrrhetinic acid; apoptosis; HL-60 cells; mitochondria; caspase-3

In this study we investigate the molecular mechanisms of caspases and mitochondria in the extrinsic and intrinsic signal apoptosis pathways in human leukemia HL-60 cells after in vitro exposure to 18α-glycyrrhetinic acid (18α-GA). Cells were exposed to 18α-GA at various concentrations for various ti...