Antibody Levels to Recombinant Tick Calreticulin Increase in Humans after Exposure to Ixodes scapularis (Say) and Are Correlated with Tick Engorgement Indices

• Published in: American journal of epidemiology Vol. 149; no. 8; pp. 777 - 784
• Main Authors: Sanders, Martin L., Glass, Gregory E., Nadelman, Robert B., Wormser, Gary P., Scott, Alan L., Raha, Syamal, Ritchie, Bruce C., Jaworski, Deborah C., Schwartz, Brian S.
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 15.04.1999
• Subjects: Adult; Aged; Animals; Antibodies - immunology; antibody; Bacterial diseases; biologic marker; Biological and medical sciences; Bites and Stings - diagnosis; Bites and Stings - immunology; Borrelia infections; Calcium-Binding Proteins - immunology; Calreticulin; Enzyme-Linked Immunosorbent Assay; Erythema Chronicum Migrans - diagnosis; Erythema Chronicum Migrans - immunology; Feeding Behavior; Female; Human bacterial diseases; Humans; Immunoblotting; Infectious diseases; Ixodes; Ixodes - immunology; Ixodes scapularis; Ixodidae; Lyme disease; Male; Medical sciences; Middle Aged; New York; Recombinant Proteins - immunology; Ribonucleoproteins - immunology; Sensitivity and Specificity; tick; Tropical bacterial diseases; United States; North America; America; New York; Parasitiformes; Human; Lyme disease; Antibody; Borrelia infection; Biological marker; Exposure; Epidemiology; Ixodes scapularis; Infection; Arachnida; Acari; Ixodida; Arthropoda; Bacteriosis; Diagnosis; Invertebrata; Molecular biology; Ixodidae; Public health; Spirachaetosis

The antibody responses of subjects who presented with a definite Ixodes scapularis (Say) tick bite were measured to determine the utility of the antibody response against recombinant tick calreticulin (rTC) as a biologic marker of tick exposure. Subjects bitten by l. scapularis evidenced an increase...