Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas

• Published in: Frontiers in immunology Vol. 11; p. 550624
• Main Authors: Souza De Lima, Dhêmerson, Bomfim, Caio C B, Leal, Vinícius N C, Reis, Edione C, Soares, Jaíne L S, Fernandes, Fernanda P, Amaral, Eduardo P, Loures, Flavio V, Ogusku, Mauricio M, Lima, Maria R D'Imperio, Sadahiro, Aya, Pontillo, Alessandra
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.10.2020
• Subjects: Adult; Alleles; Biomarkers; Brazil - epidemiology; Cohort Studies; Cytokines - metabolism; Disease Susceptibility; Female; Gene Expression Profiling; Genetic Predisposition to Disease; Genetic Variation; genetics; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; Humans; Immunology; inflammasome; Inflammasomes - metabolism; Inflammation Mediators - metabolism; Male; Middle Aged; Mycobacterium tuberculosis - physiology; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Nlrc4; NLRP3; Patient Outcome Assessment; Polymorphism, Single Nucleotide; Population Surveillance; tuberculosis; Tuberculosis - epidemiology; Tuberculosis - etiology; Tuberculosis - metabolism; Tuberculosis - prevention & control; Virulence; Brazil; Nlrc4; NLRP3; genetics; inflammasome; tuberculosis

The interplay between (Mtb) and humans is multifactorial. The susceptibility/resistance profile and the establishment of clinical tuberculosis (TB) still remains elusive. The gain-of-function variant rs10754558 in the gene (found in 30% of the world population) confers protection against the develop...