SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature

• Published in: Frontiers in endocrinology (Lausanne) Vol. 11; p. 596898
• Main Authors: Fignani, Daniela, Licata, Giada, Brusco, Noemi, Nigi, Laura, Grieco, Giuseppina E., Marselli, Lorella, Overbergh, Lut, Gysemans, Conny, Colli, Maikel L., Marchetti, Piero, Mathieu, Chantal, Eizirik, Decio L., Sebastiani, Guido, Dotta, Francesco
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.11.2020
• Subjects: angiotensin I-converting enzyme type 2 (ACE2); Angiotensin-Converting Enzyme 2 - metabolism; beta-cell; Cells, Cultured; COVID-19; COVID-19 - metabolism; COVID-19 - pathology; COVID-19 - virology; Cytokines - metabolism; diabetes; Endocrinology; human pancreatic islets; Humans; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - virology; Microvessels - metabolism; Microvessels - virology; Pancreas - metabolism; Pancreas - virology; SARS-CoV-2; SARS-CoV-2 - isolation & purification; COVID-19; SARS-CoV-2; human pancreatic islets; beta-cell; inflammation; angiotensin I-converting enzyme type 2 (ACE2); diabetes

Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the recent data highlighting an association between COVID-19 and diabetes, a detailed analysis aimed at evaluating ACE2 expre...