Analysis of the lncRNA–miRNA–mRNA Network Reveals a Potential Regulatory Mechanism of EGFR-TKI Resistance in NSCLC

• Published in: Frontiers in genetics Vol. 13; p. 851391
• Main Authors: Ding, Dandan, Zhang, Jufeng, Luo, Zhiming, Wu, Huazhen, Lin, Zexiao, Liang, Weicheng, Xue, Xingyang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.04.2022
• Subjects: drug resistance; EGFR-TKIs; Genetics; LINC01128; long non-coding RNA; lung cancer-diagnosis; EGFR-TKIs; LINC01128; long non-coding RNA; drug resistance; lung cancer-diagnosis

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are widely used for patients with EGFR-mutated lung cancer. Despite its initial therapeutic efficacy, most patients eventually develop drug resistance, which leads to a poor prognosis in lung cancer patients. Previous investigat...