Hyperenhanced Rim Surrounding Liver Metastatic Tumors in the Postvascular Phase of Sonazoid-Enhanced Ultrasonography: A Histological Indication of the Presence of Kupffer Cells

• Published in: Oncology Vol. 89; no. Suppl 2; pp. 33 - 41
• Main Authors: Tochio, Hitoshi, Sugahara, Masafumi, Imai, Yukihiro, Tei, Hiroshi, Suginoshita, Yoshiyuki, Imawsaki, Nobuhiro, Sasaki, Ichiro, Hamada, Michio, Minowa, Kazushi, Inokuma, Tetsuo, Kudo, Masatoshi
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.11.2015
• Subjects: Adult; Aged; Aged, 80 and over; Cancer therapies; Care and treatment; Clinical Study; Contrast Media - pharmacokinetics; Diagnosis; Female; Ferric Compounds - pharmacokinetics; Follow-Up Studies; Health aspects; Humans; Image Enhancement - methods; Iron - pharmacokinetics; Kupffer Cells - diagnostic imaging; Kupffer Cells - metabolism; Kupffer Cells - pathology; Liver cancer; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - metabolism; Liver Neoplasms - secondary; Liver tumors; Male; Metastasis; Middle Aged; Neoplasm Staging; Oncology; Oxides - pharmacokinetics; Prognosis; Tissue Distribution; Ultrasonic imaging; Ultrasonography; Ultrasound imaging; Japan; Programmed cell death-1 antibody; Liver cancer; Kupffer cell; Sonazoid; Contrast-enhanced ultrasonography; CD8-positive T cell

Aim: A hyperenhanced rim (termed ‘HER') in the postvascular phase is detected in some cases of liver metastasis by Sonazoid-enhanced ultrasonography (US). Here, the association of the HER with histological features was investigated to clarify the cause of this characteristic imaging pattern. Su...