Macrophage: A Cell With Many Faces and Functions in Tuberculosis

• Published in: Frontiers in immunology Vol. 13; p. 747799
• Main Authors: Ahmad, Faraz, Rani, Anshu, Alam, Anwar, Zarin, Sheeba, Pandey, Saurabh, Singh, Hina, Hasnain, Seyed Ehtesham, Ehtesham, Nasreen Zafar
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.05.2022
• Subjects: Immunology; innate immunity; macrophage heterogeneity; metabolic reprogramming; Mycobacterium tuberculosis; phenotype switching; trained immunity; macrophage heterogeneity; Mycobacterium tuberculosis; innate immunity; trained immunity; phenotype switching; metabolic reprogramming

Mycobacterium tuberculosis ( Mtb ) is the causative agent of human tuberculosis (TB) which primarily infects the macrophages. Nearly a quarter of the world’s population is infected latently by Mtb . Only around 5%–10% of those infected develop active TB disease, particularly during suppressed host i...