Inhibition of tiRNA-Gly-GCC ameliorates neointimal formation via CBX3-mediated VSMCs phenotypic switching
tRNA-derived fragments (tRFs) are a new class of non-coding RNAs involved in a variety of pathological processes, but their biological functions and mechanisms in human aortic smooth muscle cells (HASMCs) phenotype transition and vascular intimal hyperplasia are unclear. tiRNA-Gly-GCC is upregulated...
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| Published in | Frontiers in cardiovascular medicine Vol. 10; p. 1030635 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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| Abstract | tRNA-derived fragments (tRFs) are a new class of non-coding RNAs involved in a variety of pathological processes, but their biological functions and mechanisms in human aortic smooth muscle cells (HASMCs) phenotype transition and vascular intimal hyperplasia are unclear.
tiRNA-Gly-GCC is upregulated in synthetic HASMCs, atherosclerotic arteries, plasma, and the balloon injured carotid artery of rats. Functionally, the inhibition of tiRNA-Gly-GCC represses HASMCs proliferation, migration, and reversed dedifferentiation, whereas the overexpression of tiRNA- Gly-GCC have contrary effects. Mechanistically, tiRNA-Gly-GCC performs these functions on HASMCs
downregulating chromobox protein homolog 3 (CBX3). Finally, the inhibition of tiRNA-Gly-GCC could ameliorate neointimal formation after vascular injury
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tiRNA-Gly-GCC is a mediator of HASMCs phenotypic switching by targeting CBX3 and inhibition of tiRNA-Gly-GCC suppresses neointimal formation. |
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| AbstractList | Background and aimtRNA-derived fragments (tRFs) are a new class of non-coding RNAs involved in a variety of pathological processes, but their biological functions and mechanisms in human aortic smooth muscle cells (HASMCs) phenotype transition and vascular intimal hyperplasia are unclear.Methods/resultstiRNA-Gly-GCC is upregulated in synthetic HASMCs, atherosclerotic arteries, plasma, and the balloon injured carotid artery of rats. Functionally, the inhibition of tiRNA-Gly-GCC represses HASMCs proliferation, migration, and reversed dedifferentiation, whereas the overexpression of tiRNA- Gly-GCC have contrary effects. Mechanistically, tiRNA-Gly-GCC performs these functions on HASMCs via downregulating chromobox protein homolog 3 (CBX3). Finally, the inhibition of tiRNA-Gly-GCC could ameliorate neointimal formation after vascular injury in vivo.ConclusionstiRNA-Gly-GCC is a mediator of HASMCs phenotypic switching by targeting CBX3 and inhibition of tiRNA-Gly-GCC suppresses neointimal formation. tRNA-derived fragments (tRFs) are a new class of non-coding RNAs involved in a variety of pathological processes, but their biological functions and mechanisms in human aortic smooth muscle cells (HASMCs) phenotype transition and vascular intimal hyperplasia are unclear. tiRNA-Gly-GCC is upregulated in synthetic HASMCs, atherosclerotic arteries, plasma, and the balloon injured carotid artery of rats. Functionally, the inhibition of tiRNA-Gly-GCC represses HASMCs proliferation, migration, and reversed dedifferentiation, whereas the overexpression of tiRNA- Gly-GCC have contrary effects. Mechanistically, tiRNA-Gly-GCC performs these functions on HASMCs downregulating chromobox protein homolog 3 (CBX3). Finally, the inhibition of tiRNA-Gly-GCC could ameliorate neointimal formation after vascular injury . tiRNA-Gly-GCC is a mediator of HASMCs phenotypic switching by targeting CBX3 and inhibition of tiRNA-Gly-GCC suppresses neointimal formation. tiRNA-Gly-GCC produced under stress situation act as vascular smooth muscle cells (VSMCs) phenotypic switching regulator via targeting CBX3 through a post-transcriptional mechanism that leading to VSMCs transition from contractile to synthetic phenotype and causing neointimal formation. tRNA-derived fragments (tRFs) are a new class of non-coding RNAs involved in a variety of pathological processes, but their biological functions and mechanisms in human aortic smooth muscle cells (HASMCs) phenotype transition and vascular intimal hyperplasia are unclear.Background and aimtRNA-derived fragments (tRFs) are a new class of non-coding RNAs involved in a variety of pathological processes, but their biological functions and mechanisms in human aortic smooth muscle cells (HASMCs) phenotype transition and vascular intimal hyperplasia are unclear.tiRNA-Gly-GCC is upregulated in synthetic HASMCs, atherosclerotic arteries, plasma, and the balloon injured carotid artery of rats. Functionally, the inhibition of tiRNA-Gly-GCC represses HASMCs proliferation, migration, and reversed dedifferentiation, whereas the overexpression of tiRNA- Gly-GCC have contrary effects. Mechanistically, tiRNA-Gly-GCC performs these functions on HASMCs via downregulating chromobox protein homolog 3 (CBX3). Finally, the inhibition of tiRNA-Gly-GCC could ameliorate neointimal formation after vascular injury in vivo.Methods/resultstiRNA-Gly-GCC is upregulated in synthetic HASMCs, atherosclerotic arteries, plasma, and the balloon injured carotid artery of rats. Functionally, the inhibition of tiRNA-Gly-GCC represses HASMCs proliferation, migration, and reversed dedifferentiation, whereas the overexpression of tiRNA- Gly-GCC have contrary effects. Mechanistically, tiRNA-Gly-GCC performs these functions on HASMCs via downregulating chromobox protein homolog 3 (CBX3). Finally, the inhibition of tiRNA-Gly-GCC could ameliorate neointimal formation after vascular injury in vivo.tiRNA-Gly-GCC is a mediator of HASMCs phenotypic switching by targeting CBX3 and inhibition of tiRNA-Gly-GCC suppresses neointimal formation.ConclusionstiRNA-Gly-GCC is a mediator of HASMCs phenotypic switching by targeting CBX3 and inhibition of tiRNA-Gly-GCC suppresses neointimal formation. |
| Author | Niu, Shuai Rong, Zhihua Li, Fengshi Liu, Changwei Di, Xiao Ni, Leng Zhang, Rui |
| AuthorAffiliation | Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China |
| AuthorAffiliation_xml | – name: Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China |
| Author_xml | – sequence: 1 givenname: Zhihua surname: Rong fullname: Rong, Zhihua – sequence: 2 givenname: Fengshi surname: Li fullname: Li, Fengshi – sequence: 3 givenname: Rui surname: Zhang fullname: Zhang, Rui – sequence: 4 givenname: Shuai surname: Niu fullname: Niu, Shuai – sequence: 5 givenname: Xiao surname: Di fullname: Di, Xiao – sequence: 6 givenname: Leng surname: Ni fullname: Ni, Leng – sequence: 7 givenname: Changwei surname: Liu fullname: Liu, Changwei |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36818350$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/s41419-022-04930-6 10.1161/CIRCRESAHA.116.309799 10.1016/j.celrep.2018.10.014 10.1016/j.omtn.2020.12.010 10.1111/jcmm.16719 10.1186/s13046-021-02024-3 10.1038/s41392-020-00217-4 10.1161/CIRCULATIONAHA.120.050553 10.1016/j.cell.2015.02.053 10.1371/journal.pone.0153780 10.1016/j.ygeno.2021.06.039 10.1038/nm.4400 10.1161/CIRCULATIONAHA.117.027799 10.1016/j.cell.2009.07.001 10.1161/ATVBAHA.117.309180 10.1111/j.1432-0436.2007.00166.x 10.1161/CIRCULATIONAHA.113.002887 10.1016/j.ymthe.2020.09.013 10.1016/j.jnutbio.2021.108866 10.1101/gad.292169.116 10.1001/jama.2013.281053 10.1093/nar/gkaa336 10.1016/j.molcel.2011.06.022 10.1093/nar/gkr529 10.1186/s13287-021-02497-1 10.1161/ATVBAHA.111.230110 10.1161/CIRCRESAHA.117.311450 10.1161/CIRCRESAHA.109.197517 10.1016/j.neuroscience.2020.03.018 10.1093/cvr/cvx236 10.1074/jbc.M115.655548 10.1172/JCI148130 10.1111/febs.15357 10.7150/thno.51963 10.1093/jmcb/mjt052 10.1038/s41419-020-2645-3 10.1016/j.omtn.2021.07.013 10.1007/s11427-014-4698-y 10.1093/nar/gkaa657 10.1093/nar/gks947 10.1161/CIRCRESAHA.113.301272 10.1016/j.ygeno.2022.110392 10.1158/0008-5472.CAN-16-3146 10.1093/bioinformatics/btp616 10.1161/CIRCULATIONAHA.121.055949 10.1073/pnas.1407361111 10.1016/j.clinbiochem.2020.07.005 10.1186/s13045-022-01270-y 10.1161/01.res.78.2.196 10.2353/ajpath.2009.080148 10.1161/CIRCULATIONAHA.120.049715 10.1038/s41569-019-0227-9 10.1161/CIRCRESAHA.120.316489 10.1038/mt.2015.124 10.1161/CIRCRESAHA.118.314240 10.1161/CIRCRESAHA.111.240150 10.1080/21655979.2022.2064206 10.1161/ATVBAHA.120.315911 10.1016/j.canlet.2019.03.012 10.1186/s12964-022-00857-9 10.1074/jbc.M111.286203 10.1186/s12935-022-02481-6 |
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| Copyright | Copyright © 2023 Rong, Li, Zhang, Niu, Di, Ni and Liu. Copyright © 2023 Rong, Li, Zhang, Niu, Di, Ni and Liu. 2023 Rong, Li, Zhang, Niu, Di, Ni and Liu |
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| Keywords | phenotypic switching neointimal formation tiRNA VSMC tRFs |
| Language | English |
| License | Copyright © 2023 Rong, Li, Zhang, Niu, Di, Ni and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Atherosclerosis and Vascular Medicine, a section of the journal Frontiers in Cardiovascular Medicine These authors have contributed equally to this work Edited by: Roberto Vazquez-Padron, University of Miami, United States Reviewed by: Yanming Li, Baylor College of Medicine, United States; Shangfu Xu, Zunyi Medical University, China; Margarita Todorova Angelova, Sorbonne Université, France |
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| References | Farina (B10) 2020; 126 Song (B7) 2014; 57 Kim (B27) 2011; 39 Pagiatakis (B38) 2012; 287 Xu (B50) 2022; 20 Robinson (B33) 2010; 26 Deng (B22) 2015; 23 Cui (B24) 2022; 13 Zhu (B34) 2021; 12 Cammas (B28) 2007; 75 Firulli (B41) 1996; 78 Thompson (B16) 2009; 138 Maguire (B8) 2020; 287 Lyons (B52) 2020; 48 Yu (B47) 2021; 11 Cheng (B9) 2009; 105 Xie (B18) 2020; 5 Kim (B17) 2020; 28 Zhu (B46) 2019; 452 Boucher (B42) 2013; 113 Huang (B30) 2017; 31 Zhang (B32) 2018; 114 Torella (B37) 2011; 109 Deng (B48) 2022; 114 Karousi (B60) 2020; 85 Pan (B20) 2021; 131 Ivanov (B21) 2014; 111 Basatemur (B2) 2019; 16 Murgai (B3) 2017; 23 (B35) 2013; 310 Yang (B55) 2022; 99 Magee (B23) 2020; 48 Dong (B12) 2021; 144 Yang (B25) 2022; 15 Zhang (B13) 2020; 11 Goodarzi (B19) 2015; 161 Fu (B61) 2021; 113 Zhu (B45) 2021; 23 Baeten (B43) 2015; 290 Han (B54) 2021; 40 Zong (B44) 2021; 26 Ostriker (B4) 2021; 144 Zhao (B1) 2017; 121 Takanashi (B29) 2009; 174 Wang (B58) 2022; 22 Sahoo (B39) 2016; 11 Choi (B26) 2012; 40 Chappell (B6) 2016; 119 Liu (B36) 2013; 128 Yang (B5) 2018; 137 Sui (B49) 2022; 13 Zhang (B56) 2014; 6 Hall (B15) 2019; 124 Lu (B40) 2017; 37 Zeng (B14) 2021; 143 Sato (B59) 2020; 434 Godoy (B57) 2018; 25 Ni (B11) 2021; 41 Xiao (B31) 2011; 31 Huang (B51) 2017; 77 Ivanov (B53) 2011; 43 He (B62) 2021; 25 |
| References_xml | – volume: 13 year: 2022 ident: B24 article-title: A novel 3’tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer. publication-title: Cell Death Dis. doi: 10.1038/s41419-022-04930-6 – volume: 119 start-page: 1313 year: 2016 ident: B6 article-title: Extensive proliferation of a subset of differentiated, yet plastic, medial vascular smooth muscle cells contributes to neointimal formation in mouse injury and atherosclerosis models. publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.116.309799 – volume: 25 start-page: 1346 year: 2018 ident: B57 article-title: Large differences in small RNA composition between human biofluids. publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.10.014 – volume: 23 start-page: 603 year: 2021 ident: B45 article-title: tRNA-derived fragments tRFGlnCTG induced by arterial injury promote vascular smooth muscle cell proliferation. publication-title: Mol Ther Nucleic Acids. doi: 10.1016/j.omtn.2020.12.010 – volume: 25 start-page: 7052 year: 2021 ident: B62 article-title: Expression profiles and potential roles of transfer RNA-derived small RNAs in atherosclerosis. publication-title: J Cell Mol Med. doi: 10.1111/jcmm.16719 – volume: 40 year: 2021 ident: B54 article-title: A 5’-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer. publication-title: J Exp Clin Cancer Res. doi: 10.1186/s13046-021-02024-3 – volume: 5 year: 2020 ident: B18 article-title: Action mechanisms and research methods of tRNA-derived small RNAs. publication-title: Signal Transduct Target Ther. doi: 10.1038/s41392-020-00217-4 – volume: 144 start-page: 455 year: 2021 ident: B4 article-title: TET2 protects against vascular smooth muscle cell apoptosis and intimal thickening in transplant vasculopathy. publication-title: Circulation. doi: 10.1161/CIRCULATIONAHA.120.050553 – volume: 161 start-page: 790 year: 2015 ident: B19 article-title: Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement. publication-title: Cell. doi: 10.1016/j.cell.2015.02.053 – volume: 11 year: 2016 ident: B39 article-title: MEF2C-MYOCD and leiomodin1 suppression by miRNA-214 promotes smooth muscle cell phenotype switching in pulmonary arterial hypertension. publication-title: PLoS One. doi: 10.1371/journal.pone.0153780 – volume: 113 start-page: 3039 year: 2021 ident: B61 article-title: Identification of transfer RNA-derived fragments and their potential roles in aortic dissection. publication-title: Genomics. doi: 10.1016/j.ygeno.2021.06.039 – volume: 23 start-page: 1176 year: 2017 ident: B3 article-title: KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis. publication-title: Nat Med. doi: 10.1038/nm.4400 – volume: 137 start-page: 1824 year: 2018 ident: B5 article-title: miR-22 is a novel mediator of vascular smooth muscle cell phenotypic modulation and neointima formation. publication-title: Circulation. doi: 10.1161/CIRCULATIONAHA.117.027799 – volume: 138 start-page: 215 year: 2009 ident: B16 article-title: Stressing out over tRNA cleavage. publication-title: Cell. doi: 10.1016/j.cell.2009.07.001 – volume: 37 start-page: 1380 year: 2017 ident: B40 article-title: Endothelial myocyte enhancer factor 2c inhibits migration of smooth muscle cells through fenestrations in the internal elastic lamina. publication-title: Arterioscler Thromb Vasc Biol. doi: 10.1161/ATVBAHA.117.309180 – volume: 75 start-page: 627 year: 2007 ident: B28 article-title: Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation. publication-title: Differentiation. doi: 10.1111/j.1432-0436.2007.00166.x – volume: 128 start-page: 2047 year: 2013 ident: B36 article-title: Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity. publication-title: Circulation. doi: 10.1161/CIRCULATIONAHA.113.002887 – volume: 28 start-page: 2340 year: 2020 ident: B17 article-title: Transfer RNA-derived small RNAs: another layer of gene regulation and novel targets for disease therapeutics. publication-title: Mol Ther. doi: 10.1016/j.ymthe.2020.09.013 – volume: 99 year: 2022 ident: B55 article-title: Inhibition of the cleaved half of tRNAGly enhances palmitic acid-induced apoptosis in human trophoblasts. publication-title: J Nutr Biochem. doi: 10.1016/j.jnutbio.2021.108866 – volume: 31 start-page: 241 year: 2017 ident: B30 article-title: Cbx3 maintains lineage specificity during neural differentiation. publication-title: Genes Dev. doi: 10.1101/gad.292169.116 – volume: 310 start-page: 2191 year: 2013 ident: B35 article-title: World Medical Association declaration of Helsinki: ethical principles for medical research involving human subjects. publication-title: JAMA. doi: 10.1001/jama.2013.281053 – volume: 48 start-page: 6223 year: 2020 ident: B52 article-title: eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function. publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkaa336 – volume: 43 start-page: 613 year: 2011 ident: B53 article-title: Angiogenin-induced tRNA fragments inhibit translation initiation. publication-title: Mol Cell. doi: 10.1016/j.molcel.2011.06.022 – volume: 39 start-page: 8329 year: 2011 ident: B27 article-title: Histone variant H3.3 stimulates HSP70 transcription through cooperation with HP1γ. publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkr529 – volume: 12 year: 2021 ident: B34 article-title: The tRNA-derived fragment 5026a inhibits the proliferation of gastric cancer cells by regulating the PTEN/PI3K/AKT signaling pathway. publication-title: Stem Cell Res Ther. doi: 10.1186/s13287-021-02497-1 – volume: 31 start-page: 1842 year: 2011 ident: B31 article-title: Chromobox protein homolog 3 is essential for stem cell differentiation to smooth muscles in vitro and in embryonic arteriogenesis. publication-title: Arterioscler Thromb Vasc Biol. doi: 10.1161/ATVBAHA.111.230110 – volume: 121 start-page: 1331 year: 2017 ident: B1 article-title: Unspliced XBP1 confers VSMC homeostasis and prevents aortic aneurysm formation via FoxO4 interaction. publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.117.311450 – volume: 105 start-page: 158 year: 2009 ident: B9 article-title: MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.109.197517 – volume: 434 start-page: 44 year: 2020 ident: B59 article-title: Stress induced tRNA Halves (tiRNAs) as biomarkers for stroke and stroke therapy; pre-clinical study. publication-title: Neuroscience. doi: 10.1016/j.neuroscience.2020.03.018 – volume: 114 start-page: 443 year: 2018 ident: B32 article-title: Cbx3 inhibits vascular smooth muscle cell proliferation, migration, and neointima formation. publication-title: Cardiovasc Res. doi: 10.1093/cvr/cvx236 – volume: 290 start-page: 16226 year: 2015 ident: B43 article-title: Differential regulation of NOTCH2 and NOTCH3 contribute to their unique functions in vascular smooth muscle cells. publication-title: J Biol Chem. doi: 10.1074/jbc.M115.655548 – volume: 131 year: 2021 ident: B20 article-title: Inflammatory cytokine-regulated tRNA-derived fragment tRF-21 suppresses pancreatic ductal adenocarcinoma progression. publication-title: J Clin Invest. doi: 10.1172/JCI148130 – volume: 287 start-page: 5260 year: 2020 ident: B8 article-title: Noncoding RNAs in vascular smooth muscle cell function and neointimal hyperplasia. publication-title: FEBS J. doi: 10.1111/febs.15357 – volume: 11 start-page: 461 year: 2021 ident: B47 article-title: tRNA-derived fragments: mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections. publication-title: Theranostics. doi: 10.7150/thno.51963 – volume: 6 start-page: 172 year: 2014 ident: B56 article-title: Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection. publication-title: J Mol Cell Biol. doi: 10.1093/jmcb/mjt052 – volume: 11 year: 2020 ident: B13 article-title: LncRNA ANRIL acts as a modular scaffold of WDR5 and HDAC3 complexes and promotes alteration of the vascular smooth muscle cell phenotype. publication-title: Cell Death Dis. doi: 10.1038/s41419-020-2645-3 – volume: 26 start-page: 295 year: 2021 ident: B44 article-title: 5’-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection. publication-title: Mol Ther Nucleic Acids. doi: 10.1016/j.omtn.2021.07.013 – volume: 57 start-page: 826 year: 2014 ident: B7 article-title: miRNAs and lncRNAs in vascular injury and remodeling. publication-title: Sci China Life Sci. doi: 10.1007/s11427-014-4698-y – volume: 48 start-page: 9433 year: 2020 ident: B23 article-title: On the expanding roles of tRNA fragments in modulating cell behavior. publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkaa657 – volume: 40 start-page: 11321 year: 2012 ident: B26 article-title: Suppression and recovery of BRCA1-mediated transcription by HP1γ via modulation of promoter occupancy. publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks947 – volume: 113 start-page: 975 year: 2013 ident: B42 article-title: A receptor-specific function for NOTCH2 in mediating vascular smooth muscle cell growth arrest through cyclin-dependent kinase inhibitor 1B. publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.113.301272 – volume: 114 year: 2022 ident: B48 article-title: A 5’-tiRNA fragment that inhibits proliferation and migration of laryngeal squamous cell carcinoma by targeting PIK3CD. publication-title: Genomics. doi: 10.1016/j.ygeno.2022.110392 – volume: 77 start-page: 3194 year: 2017 ident: B51 article-title: tRF/miR-1280 suppresses stem cell-like cells and metastasis in colorectal cancer. publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-16-3146 – volume: 26 start-page: 139 year: 2010 ident: B33 article-title: edgeR: a bioconductor package for differential expression analysis of digital gene expression data. publication-title: Bioinformatics. doi: 10.1093/bioinformatics/btp616 – volume: 144 start-page: 1856 year: 2021 ident: B12 article-title: CARMN is an evolutionarily conserved smooth muscle cell-specific LncRNA that maintains contractile phenotype by binding myocardin. publication-title: Circulation. doi: 10.1161/CIRCULATIONAHA.121.055949 – volume: 111 start-page: 18201 year: 2014 ident: B21 article-title: G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. publication-title: Proc Natl Acad Sci U.S.A. doi: 10.1073/pnas.1407361111 – volume: 85 start-page: 20 year: 2020 ident: B60 article-title: A novel, mitochondrial, internal tRNA-derived RNA fragment possesses clinical utility as a molecular prognostic biomarker in chronic lymphocytic leukemia. publication-title: Clin Biochem. doi: 10.1016/j.clinbiochem.2020.07.005 – volume: 15 year: 2022 ident: B25 article-title: A novel tRNA-derived fragment AS-tDR-007333 promotes the malignancy of NSCLC via the HSPB1/MED29 and ELK4/MED29 axes. publication-title: J Hematol Oncol. doi: 10.1186/s13045-022-01270-y – volume: 78 start-page: 196 year: 1996 ident: B41 article-title: Myocyte enhancer binding factor-2 expression and activity in vascular smooth muscle cells. Association with the activated phenotype. publication-title: Circ Res. doi: 10.1161/01.res.78.2.196 – volume: 174 start-page: 309 year: 2009 ident: B29 article-title: Heterochromatin protein 1gamma epigenetically regulates cell differentiation and exhibits potential as a therapeutic target for various types of cancers. publication-title: Am J Pathol. doi: 10.2353/ajpath.2009.080148 – volume: 143 start-page: 354 year: 2021 ident: B14 article-title: Circular RNA circMAP3K5 Acts as a microRNA-22-3p sponge to promote resolution of intimal hyperplasia via TET2-mediated smooth muscle cell differentiation. publication-title: Circulation. doi: 10.1161/CIRCULATIONAHA.120.049715 – volume: 16 start-page: 727 year: 2019 ident: B2 article-title: Vascular smooth muscle cells in atherosclerosis. publication-title: Nat Rev Cardiol. doi: 10.1038/s41569-019-0227-9 – volume: 126 start-page: e120 year: 2020 ident: B10 article-title: miR-128-3p is a novel regulator of vascular smooth muscle cell phenotypic switch and vascular diseases. publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.120.316489 – volume: 23 start-page: 1622 year: 2015 ident: B22 article-title: Respiratory syncytial virus utilizes a tRNA fragment to suppress antiviral responses through a novel targeting mechanism. publication-title: Mol Ther. doi: 10.1038/mt.2015.124 – volume: 124 start-page: 498 year: 2019 ident: B15 article-title: Circ_Lrp6, a circular RNA enriched in vascular smooth muscle cells, acts as a sponge regulating miRNA-145 function. publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.118.314240 – volume: 109 start-page: 880 year: 2011 ident: B37 article-title: MicroRNA-133 controls vascular smooth muscle cell phenotypic switch in vitro and vascular remodeling in vivo. publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.111.240150 – volume: 13 start-page: 10617 year: 2022 ident: B49 article-title: The biological behavior of tRNA-derived fragment tRF-Leu-AAG in pancreatic cancer cells. publication-title: Bioengineered. doi: 10.1080/21655979.2022.2064206 – volume: 41 start-page: 2399 year: 2021 ident: B11 article-title: A smooth muscle cell-enriched long noncoding RNA regulates cell plasticity and atherosclerosis by interacting with serum response factor. publication-title: Arterioscler Thromb Vasc Biol. doi: 10.1161/ATVBAHA.120.315911 – volume: 452 start-page: 31 year: 2019 ident: B46 article-title: tRNA-derived fragments and tRNA halves: the new players in cancers. publication-title: Cancer Lett. doi: 10.1016/j.canlet.2019.03.012 – volume: 20 year: 2022 ident: B50 article-title: tRF-Val-CAC-016 modulates the transduction of CACNA1d-mediated MAPK signaling pathways to suppress the proliferation of gastric carcinoma. publication-title: Cell Commun Signal. doi: 10.1186/s12964-022-00857-9 – volume: 287 start-page: 8361 year: 2012 ident: B38 article-title: A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression. publication-title: J Biol Chem. doi: 10.1074/jbc.M111.286203 – volume: 22 year: 2022 ident: B58 article-title: Plasma tRNA-derived small RNAs signature as a predictive and prognostic biomarker in lung adenocarcinoma. publication-title: Cancer Cell Int. doi: 10.1186/s12935-022-02481-6 |
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| Snippet | tRNA-derived fragments (tRFs) are a new class of non-coding RNAs involved in a variety of pathological processes, but their biological functions and mechanisms... tiRNA-Gly-GCC produced under stress situation act as vascular smooth muscle cells (VSMCs) phenotypic switching regulator via targeting CBX3 through a... Background and aimtRNA-derived fragments (tRFs) are a new class of non-coding RNAs involved in a variety of pathological processes, but their biological... |
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| SubjectTerms | Cardiovascular Medicine neointimal formation phenotypic switching tiRNA tRFs VSMC |
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| Title | Inhibition of tiRNA-Gly-GCC ameliorates neointimal formation via CBX3-mediated VSMCs phenotypic switching |
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