Role of Proprotein Convertase Subtilisin/Kexin Type 9 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts

• Published in: Frontiers in endocrinology (Lausanne) Vol. 11; p. 607144
• Main Authors: Lee, Ga Eun, Kim, Jinjoo, Lee, Jihei Sara, Ko, JaeSang, Lee, Eun Jig, Yoon, Jin Sook
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.01.2021
• Subjects: adipogenesis; Endocrinology; Graves’ orbitopathy; inflammation; oxidative stress; PCSK9; proprotein convertase subtilisin/kexin type 9; proprotein convertase subtilisin/kexin type 9; thyroid eye disease; adipogenesis; inflammation; PCSK9; Graves’ orbitopathy; oxidative stress

The proprotein convertase subtilisin/kexin type 9 (PCSK9) has been implicated in the pathogenesis of inflammatory diseases. We sought to investigate the role of PCSK9 in the pathogenesis of Graves' orbitopathy (GO) and whether it may be a legitimate target for treatment. The was compared betwee...