Functional Genomic Analysis of Amphetamine Sensitivity in Drosophila

• Published in: Frontiers in psychiatry Vol. 13; p. 831597
• Main Authors: Karam, Caline S., Williams, Brenna L., Morozova, Irina, Yuan, Qiaoping, Panarsky, Rony, Zhang, Yuchao, Hodgkinson, Colin A., Goldman, David, Kalachikov, Sergey, Javitch, Jonathan A.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.02.2022
• Subjects: amphetamine; DGRP; dopamine transporter; Drosophila; Psychiatry; psychostimulants; transcriptomic (RNA-Seq); dopamine transporter; psychostimulants; transcriptomic (RNA-Seq); S6K (70-kDa ribosomal protein S6 kinase); Drosophila; amphetamine; mammalian target of rapamycin (mTOR); DGRP

Abuse of psychostimulants, including amphetamines (AMPHs), is a major public health problem with profound psychiatric, medical, and psychosocial complications. The actions of these drugs at the dopamine transporter (DAT) play a critical role in their therapeutic efficacy as well as their liability f...