Upf2-Mediated Nonsense-Mediated Degradation Pathway Involved in Genetic Compensation of TrpA1 Knockout Mutant Silkworm (Bombyx mori)

• Published in: Insects (Basel, Switzerland) Vol. 15; no. 5; p. 313
• Main Authors: Wang, Dong-Yue, Zhu, Juan, Zhang, Yi-Zhong, Cui, Qian-Yi, Wang, Shan-Shan, Ning, Yang-Wei, Shen, Xing-Jia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.04.2024
• Subjects: BmTrpA1; Bombyx mori; Codons; Compensation; CRISPR; CRISPR-Cas systems; CRISPR/Cas9; Degradation; Diapause; Eggs; Embryogenesis; Embryonic growth stage; Gene deletion; Genes; genetic compensation response; Genetic modification; homozygosity; Humidity; Insects; Lepidoptera; Molecular modelling; Mutants; Mutation; Nonsense mutation; nonsense-mediated mRNA degradation pathway; Offspring; phenotype; Phenotypes; progeny; Proteins; RNA interference; RNA-mediated interference; Silkworms; stop codon; Temperature; United States > US; Japan; genetic compensation response; Bombyx mori; CRISPR/Cas9; BmTrpA1; nonsense-mediated mRNA degradation pathway

Genetic mutations leading to premature termination codons are known to have detrimental effects. Using the Lepidoptera model insect, the silkworm (Bombyx mori), we explored the genetic compensatory response triggered by mutations with premature termination codons. Additionally, we delved into the mo...