Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan With Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration

• Published in: Frontiers in cell and developmental biology Vol. 10; p. 856261
• Main Authors: Hayes, Anthony J, Farrugia, Brooke L, Biose, Ifechukwude J, Bix, Gregory J, Melrose, James
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.04.2022
• Subjects: cartilage repair; Cell and Developmental Biology; perlecan; perlecan domain-I; repair biology; repair of blood brain barrier; vascular repair; growth factor delivery; perlecan; perlecan domain-I; repair biology; cartilage repair; perlecan domain-V; repair of blood brain barrier; vascular repair

This review highlights the multifunctional properties of perlecan (HSPG2) and its potential roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose, lymphoreticular, bone and bone marrow stroma and in neural tissues. Perlecan has roles in angiogenesis, tissue d...