Inhibition of steroid-induced cataract in rat eyes by administration of vitamin-E ophthalmic solution

• Published in: Ophthalmic research Vol. 28 Suppl 2; p. 64
• Main Authors: Kojima, M, Shui, Y B, Murano, H, Sasaki, K
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.1996
• Subjects: Animals; Body Weight; Cataract - chemically induced; Cataract - pathology; Cataract - prevention & control; Disease Models, Animal; Glucocorticoids - toxicity; Lens, Crystalline - drug effects; Lens, Crystalline - pathology; Lens, Crystalline - radiation effects; Light; Male; Ophthalmic Solutions; Prednisolone - analogs & derivatives; Prednisolone - toxicity; Rats; Rats, Inbred BN; Scattering, Radiation; Vitamin E - administration & dosage; X-Rays
• DOI: 10.1159/000267958
• ISSN: 0030-3747

The efficacy of a vitamin-E (VE) ophthalmic solution was evaluated on a newly developed rat steroid-induced cataract model. Brown Norway rats irradiated with 2 Gy X-ray, right eyes only, were divided into 5 groups: the control group; 2 steroid (1 mg/kg/day)-treated groups with topic (Top) and systemic (Sys) administration, and 2 VE-treated groups, 1 with the same treatment as the Top group with the addition of 5% VE twice a day (Top + VE) and 1 with the same treatment as the Sys group with 5% VE twice a day (SYS + VE). The lens changes were documented with a Scheimpflug camera and changes in light scattering were evaluated quantitatively. The VE-treated groups (Top + VE and Sys + VE) showed a significant inhibition of the increase in the opaque area compared with each of the non-VE-treated groups. The VE ophthalmic solution was strong enough to prevent steroid-induced cataract in rats.