Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK/PGC-1α pathway - Zhang, Cheng-Lin; Feng, Han; Li, Li; Wang, Jin-Yu; Wu, Dan; Hao, Yan-Ting; Wang, Zheng; Zhang, Yan; Wu, Li-Ling (Biochimica et biophysica acta. General subjects, 2017)
Keywords: Acetylation - drug effects; adenine; adenosine triphosphate; adipokines; AMP-activated protein kinase; AMP-Activated Protein Kinases - antagonists & inhibitors; AMP-Activated Protein Kinases - metabolism; Animals; biogenesis; C1q/tumor necrosis factor-related protein-3; cardiomyocytes; cardiovascular diseases; Cells, Cultured; cytochrome b; genes; homeostasis; Hypoxia - metabolism; mitochondria; Mitochondrial biogenesis; mitochondrial DNA; Mitochondrial Proteins - metabolism; Models, Biological; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - ultrastructure; necrosis; Organelle Biogenesis; oxidative phosphorylation; Oxygen - pharmacology; oxygen consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism; Peroxisome proliferators activated receptor-γ co-activator-1α; quantitative polymerase chain reaction; rats; Rats, Sprague-Dawley; Signal Transduction - drug effects; Sirtuin 1 - metabolism; Sirtuin1; small interfering RNA; transcription factors; transmission electron microscopes; Tumor Necrosis Factors - metabolism; Western blotting; ATP-5β; mtDNA; Cyt B; Peroxisome proliferators activated receptor-γ co-activator-1α; NRVMs; OXPHOS; FCCP; H/R; PGC-1α; AMP-activated protein kinase; SIRT1; AraA; NAD; CTRP3; Mitochondrial biogenesis; Mfn-2; NRF-1; AMPK; TFAM; C1q/tumor necrosis factor-related protein-3; Sirtuin1; OCR