Eriodictyol as a Potential Candidate Inhibitor of Sortase A Protects Mice From Methicillin-Resistant Staphylococcus aureus -Induced Pneumonia

• Published in: Frontiers in microbiology Vol. 12; p. 635710
• Main Authors: Wang, Li, Li, Qianxue, Li, Jiaxin, Jing, Shisong, Jin, Yajing, Yang, Lin, Yu, Hangqian, Wang, Dacheng, Wang, Tiedong, Wang, Lin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.02.2021
• Subjects: antivirulence; eriodictyol; inhibitor; methicillin-resistant Staphylococcus aureus; Microbiology; pneumonia; sortase A; methicillin-resistant Staphylococcus aureus; sortase A; inhibitor; pneumonia; eriodictyol; antivirulence

New anti-infective approaches are urgently needed to control multidrug-resistant (MDR) pathogens, such as methicillin-resistant (MRSA). Sortase A (SrtA) is a membrane-bound cysteine transpeptidase that plays an essential role in the catalysis of covalent anchoring of surface proteins to the cell wal...