The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer
Colorectal cancer (CRC) has the second highest mortality rate among all cancers worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment methods have significantly prolonged the survival of patients with CRC. Recently, the emergence of tumor immunotherapy represented b...
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| Published in | Frontiers in immunology Vol. 12; p. 792691 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
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Frontiers Media S.A
02.12.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Colorectal cancer (CRC) has the second highest mortality rate among all cancers worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment methods have significantly prolonged the survival of patients with CRC. Recently, the emergence of tumor immunotherapy represented by immune checkpoint inhibitors (ICIs) has brought new immunotherapy options for the treatment of advanced CRC. As the efficacy of ICIs is closely related to the tumor immune microenvironment (TME), it is necessary to clarify the relationship between the immune microenvironment of CRC and the efficacy of immunotherapy to ensure that the appropriate drugs are selected. We herein review the latest research progress in the immune microenvironment and strategies related to immunotherapy for CRC. We hope that this review helps in the selection of appropriate treatment strategies for CRC patients. |
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| AbstractList | Colorectal cancer (CRC) has the second highest mortality rate among all cancers worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment methods have significantly prolonged the survival of patients with CRC. Recently, the emergence of tumor immunotherapy represented by immune checkpoint inhibitors (ICIs) has brought new immunotherapy options for the treatment of advanced CRC. As the efficacy of ICIs is closely related to the tumor immune microenvironment (TME), it is necessary to clarify the relationship between the immune microenvironment of CRC and the efficacy of immunotherapy to ensure that the appropriate drugs are selected. We herein review the latest research progress in the immune microenvironment and strategies related to immunotherapy for CRC. We hope that this review helps in the selection of appropriate treatment strategies for CRC patients. |
| Author | Wu, Changping Chen, Yaping Zheng, Xiao |
| AuthorAffiliation | 2 Department of Oncology, The Third Affiliated Hospital of Soochow University , Changzhou , China 1 Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University , Changzhou , China |
| AuthorAffiliation_xml | – name: 1 Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University , Changzhou , China – name: 2 Department of Oncology, The Third Affiliated Hospital of Soochow University , Changzhou , China |
| Author_xml | – sequence: 1 givenname: Yaping surname: Chen fullname: Chen, Yaping organization: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China – sequence: 2 givenname: Xiao surname: Zheng fullname: Zheng, Xiao organization: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China – sequence: 3 givenname: Changping surname: Wu fullname: Wu, Changping organization: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34925375$$D View this record in MEDLINE/PubMed |
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| Keywords | bevacizumab colorectal cancer immune microenvironment PD-1 immunotherapy |
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| Title | The Role of the Tumor Microenvironment and Treatment Strategies in Colorectal Cancer |
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